靶向超声造影在乳腺癌诊断与治疗中的研究进展
|
摘要
乳腺癌是女性常见恶性肿瘤之一,发病机制尚未明确,早期诊断和治疗可以改善患者预后。随着超声分子影像技术的发展,靶向超声造影为乳腺癌的诊断及治疗提供了新的技术手段。本文对靶向超声造影在乳腺癌诊断和治疗中的应用进展做一综述。
Breast cancer is one of the common malignant tumors in women,of which the pathogenesis is still unclear.Early diagnosis and treatment can improve the prognosis of patients with breast cancer.With the development of ultrasound molecular imaging technologies,targeted ultrasound molecular imaging technology provides a new method for diagnosis and treatment of breast cancer.The application progresses of targeted ultrasound contrast imaging in diagnosis and treatment of breast cancer were reviewed in this article.
Breast cancer is one of the common malignant tumors in women,of which the pathogenesis is still unclear.Early diagnosis and treatment can improve the prognosis of patients with breast cancer.With the development of ultrasound molecular imaging technologies,targeted ultrasound molecular imaging technology provides a new method for diagnosis and treatment of breast cancer.The application progresses of targeted ultrasound contrast imaging in diagnosis and treatment of breast cancer were reviewed in this article.
引文
[1] Lukong KE. Understanding breast cancer—The long and winding road. BBA Clin, 2017,7:64-77.
[2] Zhang J, Li X, Huang R, et al. A nomogram to predict the probability of axillary lymph node metastasis in female patients with breast cancer in China: A nationwide, multicenter, 10-year epidemiological study. Oncotarget, 2017,8(21):35311-35325.
[3] Stewart BW, Wild CP. World Cancer Report 2014: International Agency for Research on Cancer. Geneva: World Health Organization, 2014:16-53.
[4] 孙志华,邴晖,刘益巧,等.乳腺癌靶向治疗的研究进展.生命科学研究,2017,21(3):275-282.
[5] 罗娅红.乳腺癌的影像学诊断进展和研究方向.中国医学影像技术,2017,33(5):645-646.
[6] Yuan WH, Li AF, Chou YH, et al. Clinical andultrasonographic features of male breast tumors: A retrospective analysis. PLoS One, 2018,13(3):e0194651.
[7] Thigpen D, Kappler A, Brem R. The role of ultrasound in screening dense breasts—a review of the literature and practical solutions for implementation. Diagnostics, 2018,8(1):1-14.
[8] Bickelhaupt S, Steudle F, Paech D, et al. On a fractional order calculus model in diffusion weighted breast imaging to differentiate between malignant and benign breast lesions detected on X-ray screening mammography. PLoS One, 2017,12(4):e0176077.
[9] 汤磊磊,易维真.医学影像技术在乳腺癌中应用研究概述.临床合理用药杂志,2017,10(4):176-177.
[10] 陈雪飞.乳腺癌的超声治疗新发展趋势探究.医学信息(中旬刊),2010,5(5):1324-1325.
[11] 黄秋红,高礼善,杨晓玲,等.一种靶向蛋白质超声微泡的制备及表征.重庆科技学院学报(自然科学版),2017,19(6):63-67.
[12] Mustafi D, Fernandez S, Markiewicz E, et al. MRI reveals increased tumorigenesis following high fat feeding in a mouse model of triple-negative breast cancer. NMR Biomed, 2017,30(10).doi:10.1002/nbm.3758.
[13] You Y, Liang X, Yin T, et al. Porphyrin-grafted lipid microbubbles for the enhanced efficacy of photodynamic therapy in prostate cancer through ultrasound-controlled in situ accumulation. Theranostics, 2018,8(6):1665-1677.
[14] Baghirov H, Snipstad S, Sulheim E, et al. Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model. PLoS One, 2018,13(1):e0191102.
[15] Unger EC, Matsunaga TO,McCreery T, et al. Therapeutic applications of microbubbles. Eur J Radiol, 2002,42(2):160-168.
[16] Abou-Elkacem L, Bachawal SV, Willmann JK. Ultrasound molecular imaging: Moving toward clinical translation. Eur J Radiol, 2015,84(9):1685-1693.
[17] Bachawal SV, Jensen KC, Wilson KE, et al. Breast cancer detection by B7-H3-targeted ultrasound molecular imaging. Cancer Res, 2015,75(12):2501-2509.
[18] Xu L, Du J, Wan C, et al. Ultrasound molecular imaging of breast cancer in MCF-7 orthotopic mice using goldnanoshelled poly (lactic-co-glycolic acid) nanocapsules: A novel dual-targeted ultrasound contrast agent. Int J Nanomedicine, 2018,13:1791-1807.
[19] Li J, Tian Y, Shan D, et al. Neuropeptide Y Y_1 receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging. Biomaterials, 2017,116:106-117.
[20] Willmann JK, Bonomo L, Carla TA, et al. Ultrasound molecular imaging with BR55 in patients with breast and ovarian lesions: First-in-human results. J Clin Oncol, 2017,35(19):2133-2140.
[21] Jiang Q, Hao S, Xiao X, et al. Production and characterization of a novel long-acting Herceptin-targeted nanobubble contrast agent specific for Her-2-positive breast cancers. Breast Cancer, 2016,23(3):445-455.
[22] 李小宇,张鹏,罗文,等.携抗MUC1单克隆抗体的超声造影剂微泡制备及体外寻靶实验.现代生物医学进展,2017,17(10):1815-1817.
[23] Du J, Li XY, Hu H, et al. Preparation and imaging investigation of dual-targeted C_3F_8-filled PLGA nanobubbles as a novel ultrasound contrast agent for breast cancer. Sci Rep, 2018,8(1):3887-3901.
[24] 陈园园,徐枫,杨辉,等.构建叶酸修饰的乳腺癌靶向纳米超声造影微.中国组织工程研究,2016,20(30):4425-4433.
[25] Bekeredjian R, Kroll RD, Fein E, et al. Ultrasound targeted microbubble destruction increases capillary permeability in hepatomas. Ultrasound Med Bilo, 2007,33(10):1592-1598.
[26] Li Y, Wang P, Chen X, et al. Activation of microbubbles by low-intensity pulsed ultrasound enhances the cytotoxicity of curcumin involving apoptosis induction and cell motility inhibition in human breast cancer MDA-MB-231 cells. Ultrason Sonochem, 2016,33(16):26-36.
[27] Zhang J, Zhang Y, Liu J, et al. Targeting property and toxicity of a novel ultrasound contrast agentmicrobubble carrying the targeting and drug-loaded complex FA-CNTs-PTX on MCF7 cells. Colloids Surf B Biointerfaces, 2017,158:16-24.
[28] Song W, Luo Y, Zhao Y, et al. Magnetic nanobubbles with potential for targeted drug delivery and trimodal imaging in breast cancer: An in vitro study. Nanomedicine (Lond), 2017,12(9):991-1009.
[29] 姚元志,王志刚,张亮,等.制备叶酸受体靶向载阿霉素/黑色素多功能造影剂及体外超声/光声显像.中国介入影像与治疗学,2018,15(5):286-290.
[30] Zhao R, Liang X, Zhao B, et al. Ultrasound assisted gene and photodynamic synergistic therapy with multifunctional FOXA1-siRNA loaded porphyrin microbubbles for enhancing therapeutic efficacy for breast cancer. Biomaterials, 2018,173(8):58-70.
[31] Ji Y, Han Z, Shao L, et al. Evaluation of in vivo antitumor effects of low-frequency ultrasound-mediated miRNA-133a microbubble delivery in breast cancer. Cancer Med, 2016,5(9):2534-2543.
[32] Dai Y, Wang X, Hu H. Ultrasound-guided injections of ultrasound contrast agents and p53 gene for the treatment of rat with breast cancer. Biomedical Res, 2017,28(20):8724-8730.
[2] Zhang J, Li X, Huang R, et al. A nomogram to predict the probability of axillary lymph node metastasis in female patients with breast cancer in China: A nationwide, multicenter, 10-year epidemiological study. Oncotarget, 2017,8(21):35311-35325.
[3] Stewart BW, Wild CP. World Cancer Report 2014: International Agency for Research on Cancer. Geneva: World Health Organization, 2014:16-53.
[4] 孙志华,邴晖,刘益巧,等.乳腺癌靶向治疗的研究进展.生命科学研究,2017,21(3):275-282.
[5] 罗娅红.乳腺癌的影像学诊断进展和研究方向.中国医学影像技术,2017,33(5):645-646.
[6] Yuan WH, Li AF, Chou YH, et al. Clinical andultrasonographic features of male breast tumors: A retrospective analysis. PLoS One, 2018,13(3):e0194651.
[7] Thigpen D, Kappler A, Brem R. The role of ultrasound in screening dense breasts—a review of the literature and practical solutions for implementation. Diagnostics, 2018,8(1):1-14.
[8] Bickelhaupt S, Steudle F, Paech D, et al. On a fractional order calculus model in diffusion weighted breast imaging to differentiate between malignant and benign breast lesions detected on X-ray screening mammography. PLoS One, 2017,12(4):e0176077.
[9] 汤磊磊,易维真.医学影像技术在乳腺癌中应用研究概述.临床合理用药杂志,2017,10(4):176-177.
[10] 陈雪飞.乳腺癌的超声治疗新发展趋势探究.医学信息(中旬刊),2010,5(5):1324-1325.
[11] 黄秋红,高礼善,杨晓玲,等.一种靶向蛋白质超声微泡的制备及表征.重庆科技学院学报(自然科学版),2017,19(6):63-67.
[12] Mustafi D, Fernandez S, Markiewicz E, et al. MRI reveals increased tumorigenesis following high fat feeding in a mouse model of triple-negative breast cancer. NMR Biomed, 2017,30(10).doi:10.1002/nbm.3758.
[13] You Y, Liang X, Yin T, et al. Porphyrin-grafted lipid microbubbles for the enhanced efficacy of photodynamic therapy in prostate cancer through ultrasound-controlled in situ accumulation. Theranostics, 2018,8(6):1665-1677.
[14] Baghirov H, Snipstad S, Sulheim E, et al. Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model. PLoS One, 2018,13(1):e0191102.
[15] Unger EC, Matsunaga TO,McCreery T, et al. Therapeutic applications of microbubbles. Eur J Radiol, 2002,42(2):160-168.
[16] Abou-Elkacem L, Bachawal SV, Willmann JK. Ultrasound molecular imaging: Moving toward clinical translation. Eur J Radiol, 2015,84(9):1685-1693.
[17] Bachawal SV, Jensen KC, Wilson KE, et al. Breast cancer detection by B7-H3-targeted ultrasound molecular imaging. Cancer Res, 2015,75(12):2501-2509.
[18] Xu L, Du J, Wan C, et al. Ultrasound molecular imaging of breast cancer in MCF-7 orthotopic mice using goldnanoshelled poly (lactic-co-glycolic acid) nanocapsules: A novel dual-targeted ultrasound contrast agent. Int J Nanomedicine, 2018,13:1791-1807.
[19] Li J, Tian Y, Shan D, et al. Neuropeptide Y Y_1 receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging. Biomaterials, 2017,116:106-117.
[20] Willmann JK, Bonomo L, Carla TA, et al. Ultrasound molecular imaging with BR55 in patients with breast and ovarian lesions: First-in-human results. J Clin Oncol, 2017,35(19):2133-2140.
[21] Jiang Q, Hao S, Xiao X, et al. Production and characterization of a novel long-acting Herceptin-targeted nanobubble contrast agent specific for Her-2-positive breast cancers. Breast Cancer, 2016,23(3):445-455.
[22] 李小宇,张鹏,罗文,等.携抗MUC1单克隆抗体的超声造影剂微泡制备及体外寻靶实验.现代生物医学进展,2017,17(10):1815-1817.
[23] Du J, Li XY, Hu H, et al. Preparation and imaging investigation of dual-targeted C_3F_8-filled PLGA nanobubbles as a novel ultrasound contrast agent for breast cancer. Sci Rep, 2018,8(1):3887-3901.
[24] 陈园园,徐枫,杨辉,等.构建叶酸修饰的乳腺癌靶向纳米超声造影微.中国组织工程研究,2016,20(30):4425-4433.
[25] Bekeredjian R, Kroll RD, Fein E, et al. Ultrasound targeted microbubble destruction increases capillary permeability in hepatomas. Ultrasound Med Bilo, 2007,33(10):1592-1598.
[26] Li Y, Wang P, Chen X, et al. Activation of microbubbles by low-intensity pulsed ultrasound enhances the cytotoxicity of curcumin involving apoptosis induction and cell motility inhibition in human breast cancer MDA-MB-231 cells. Ultrason Sonochem, 2016,33(16):26-36.
[27] Zhang J, Zhang Y, Liu J, et al. Targeting property and toxicity of a novel ultrasound contrast agentmicrobubble carrying the targeting and drug-loaded complex FA-CNTs-PTX on MCF7 cells. Colloids Surf B Biointerfaces, 2017,158:16-24.
[28] Song W, Luo Y, Zhao Y, et al. Magnetic nanobubbles with potential for targeted drug delivery and trimodal imaging in breast cancer: An in vitro study. Nanomedicine (Lond), 2017,12(9):991-1009.
[29] 姚元志,王志刚,张亮,等.制备叶酸受体靶向载阿霉素/黑色素多功能造影剂及体外超声/光声显像.中国介入影像与治疗学,2018,15(5):286-290.
[30] Zhao R, Liang X, Zhao B, et al. Ultrasound assisted gene and photodynamic synergistic therapy with multifunctional FOXA1-siRNA loaded porphyrin microbubbles for enhancing therapeutic efficacy for breast cancer. Biomaterials, 2018,173(8):58-70.
[31] Ji Y, Han Z, Shao L, et al. Evaluation of in vivo antitumor effects of low-frequency ultrasound-mediated miRNA-133a microbubble delivery in breast cancer. Cancer Med, 2016,5(9):2534-2543.
[32] Dai Y, Wang X, Hu H. Ultrasound-guided injections of ultrasound contrast agents and p53 gene for the treatment of rat with breast cancer. Biomedical Res, 2017,28(20):8724-8730.