J波综合征研究进展
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摘要
随着心血管恶性事件发生率的迅猛增加,病死率居高不下,J波综合征已成为研究的热点。J波综合征是指以J波为特征合并一系列临床综合征(如早期复极综合征、Brugada综合征、特发性心室纤颤等)。这一系列临床综合征的出现有发生恶性心律失常及心脏性猝死的倾向,且其间具有相似的发病机制、心电图特征及临床意义。因此,正确识别和认识J波综合征对心血管疾病的诊断、临床治疗及干预尤为重要。
With the rapid increase of the incidence and mortality of cardiovascular malignant events,J wave syndrome has become a hot research topic. J wave syndrome refers to a series of clinical symptoms( such as early repolarization syndrome,Brugada syndrome and idiopathic ventricular fibrallatlon,etc.). The emergence of the symptoms suggests tendency of malignant arrhythmia and sudden cardiac death,with similar pathogenesis,electrocardiogram characteristics and clinical significance. It is important to recognize and understand the J wave syndrome correctly for the diagnosis,treatment and intervention of cardiovascular diseases.
With the rapid increase of the incidence and mortality of cardiovascular malignant events,J wave syndrome has become a hot research topic. J wave syndrome refers to a series of clinical symptoms( such as early repolarization syndrome,Brugada syndrome and idiopathic ventricular fibrallatlon,etc.). The emergence of the symptoms suggests tendency of malignant arrhythmia and sudden cardiac death,with similar pathogenesis,electrocardiogram characteristics and clinical significance. It is important to recognize and understand the J wave syndrome correctly for the diagnosis,treatment and intervention of cardiovascular diseases.
引文
[1]钟松美.动态心电图预警心脏性猝死[J].临床心电学杂志,2007,16(5):352-355.
[2]雷蓉,毛燕.J波的心电图诊断及临床意义探讨[J].山西医科大学学报,2012,43(8):589-591.
[3]Tomaszewski W.Changement electrocardiographiques observes chez un Homm mort de froid[J].Arch mal Coeur Vaiss,1938,3:525-528.
[4]Osborn JJ.Experimental hypothermia:respiratory and blood PHchanges in relation to cardiac function[J].Am J physiol,1953,175:389-398.
[5]Niwa N,Nerbonne JM.Molecular determinants of cardiac transient outward potassium current(I(to))expression and regulation[J].J Mol Cell Cardiol,2010,48(1):12-25.
[6]Li G,Cheng G,Wu J,et al.Drug-induced long QT syndrome in women[J].Adv Ther,2013,30(9):793-802.
[7]王观青,严干新,崔长琮.J波综合征[J].实用诊断与治疗杂志,2008,22(5):360-362.
[8]裴娟慧,浦介麟.J波综合征[J].心血管病学进展,2011,32(4):483-486.
[9]Antzelevitch C,Yan GX.J wave syndromes[J].Heart Rhythm,2010,7(4):549-558.
[10]崔长琮,严干新.急性缺血性J波和J波综合征的研究现状[J].中华心血管病杂志,2010,38(4):299-300.
[11]洪葵,熊琴梅.Brugada综合征:临床和分子生物学研究进展[J].心血管病学进展,2010,31(1):13-16.
[12]狄梦阳,白融.药物性Brugada样心电图-综合征[J].心血管病学进展,2010,31(4):501-504.
[13]王龙,赵菁,王伟民,等.右冠状动脉圆锥支痉挛出现Ⅰ型Brugada样心电图改变1例[J].中华心血管病杂志,2010,38(2):181-182.
[14]Brugada P,Brugada J.Right bundle branchblock,persistent STsegment elevation and sudden cardiac death:a distinct clinical and electrocardiographic syndrome.Amulticenterreport[J].J Am Col Cardiol,1992,20(6):1391-1396.
[15]王军,杨钧国,张守焰,等.Brugada综合征和特发性J波的临床分析[J].中华心律失常学杂志,2001,5(6):351-354.
[16]Kapplinger JD,Tester DJ,Alders M,et al An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing[J].Heart Rhythm,2010,7(1):33-46.
[17]彭颖秀.J波综合征的临床探讨[J].现代中西医结合杂志,2011,34(20):4348-4350.
[18]Yan GX,Lankipalli RS,Burke JF,et al.Ventricular repolarization components on the electrocardiogram:cellular basis and clinical significance[J].J Am Coll Cardiol,2003,42(3):401-409.
[19]Bayés de Luna A,Brugada J,Baranchuk A,et al.Current electrocardiographic criteria for diagnosis of Brugada pattern:a consensus report[J].J Electrocardiol,2012,45(5):433-442.
[20]Jastrzabski M,Kukla P.Ischemic J wave:novel risk marker for ventricular fibrillation?[J].Heart Rhythm,2009,6(6):829-835.
[21]宁爱民.Brugada综合征及其临床进展[J].心电学杂志,2004,23(4):247-253.
[22]Carrado D,Nava A,Buja G,et al.Familial cardiomyopathy underlies syndrome of right bundlebranch block,ST segment elevation and sudden death[J].J Am Coll Cardiol,1996,27(2):443-448.
[23]张清华.Brugada综合征临床处理的当今观点[J].临床心电学杂志,2003,12(3):147.
[24]何梅先,宿燕岗,刘学波,等.植入型转复除颤器治疗Brugada综合征3例[J].中华心律失常学杂志,2002,6(1):56.
[25]Shipleygn RA,Hallaran WR.The four lead electrocardrogram in200 normal men and women[J].Am Heart J,1936,11:325-345.
[26]李华,刘艳.早复临床20例分析[J].中国医师杂志,2004,6(2):235.
[27]Di Diego JM,Cordeiro JM,Goodrow RJ,et al.Ionic and cellular bassis for the predominance of the Brugada syndrome phenotype in males[J].Circulation,2002,106(15):2004-2011.
[28]Wolpert C,Veltmann C,Schimpf R,et al.Is a narrow and tall QRScomplex an ECG marker forsudden death?[J].Heart Rhythm,2008,5(9):1339-1345.
[29]Boineau JP.The early repolarization variant--an electrocardiographic enigma with both QRS and J-STT anomalies[J].J Electrocardiol,2007,40(1):3.
[30]Nam GB,Ko KH,Kim J,et al.Mode of onset of ventricular fibrillation in patients with early repolarization pattern vs.Brugada syndrome[J].Eur Heart J,2010,31(3):330-339.
[31]Derval N,Simpson CS,Birnie DH,et al.Prevalence and characteristics of early repolarization in the CASPER registry:cardiac arrest survivors with preserved ejection fraction registry[J].J Am Coll Cardiol,2011,58(7):722-728.
[32]Rosso R,Adler A,Halkin A,et al.Risk of sudden among young individuals with J waves and early repolarization:putting the evidence into perspective[J].Heart Rhythm,2011,8(6):923-929.
[33]Haissaguerre M,Derval N,Sacher F,et al.Sudden cardiac arrest associated with early replarization[J].N Engl J Med,2008,358(19):2016-2023.
[34]Rosso R,Kogan E,Belhassen B,et al.J-point elevation in survivors of primary ventricular fibrillation and matched control subjects:incidence and clinical significance[J].J Am Coll Cardiol,2008,52(15):1231-1238.
[35]Yan GX,Antzelevith C.Cellular basis for electrocardiographic Jwave[J].Circulation,1996,93(2):372-379.
[36]Otto CM,Tauxe RV,Cobb LA,et al.Ventricular fibrillation causes sudden death in Southeast Asian immigrants[J].Ann Intern Med,1984,101(1):45-47.
[37]Kalla H,Yan GX,Marinchak R.Ventricular fibrillation in a patient with prominent J(Osborn)waves and ST segment elevation in the inferior electrocardiographic leads:a Brugada syndrome variant?[J].J Cardiovasc Electrophysiol,2000,11(1):95-98.
[38]Nademanee K,Veerakul G,Chandanamattha P,et al.Prevention of ventricular fibrillation episodes in Brugada syndrome by catheter ablation over the anterior right ventricular outflow tract epicardium[J].Circulation,2011,123(12):1270-1279.
[39]Di Diego JM,Antzelevitch C.Cellular basis for ST-segment changes observed during ischemia[J].J Electrocardiol,2003,36 Suppl:1-5.
[40]封盼攀,马康华.缺血性J波和恶性心律失常[J].心血管病学进展,2011,32(2):188-190.
[41]许彩娜,刘宽芝,王战建.应激性高血糖与急性冠脉综合征[J].河北医药,2008,30(3):362.
[42]Libby P,Ridkei PM,Hansson GK,et al.Inflammation in atherosclerosis:from pathophysiology to practice[J].J Am Coll Cardiol,2009,54(23):2129-2138.
[43]吴蔚,杨希立,刘宇清,等.急性冠脉综合征缺血性J波的临床意义[J].临床心电学杂志,2013,22(4):254-255.
[44]谢玲斐,黄伟剑,张怀勤,等.含缺血性J波的急性冠脉综合征不同治疗方法的预后探讨[J].现代实用医学,2009,3(2):893-895.
[2]雷蓉,毛燕.J波的心电图诊断及临床意义探讨[J].山西医科大学学报,2012,43(8):589-591.
[3]Tomaszewski W.Changement electrocardiographiques observes chez un Homm mort de froid[J].Arch mal Coeur Vaiss,1938,3:525-528.
[4]Osborn JJ.Experimental hypothermia:respiratory and blood PHchanges in relation to cardiac function[J].Am J physiol,1953,175:389-398.
[5]Niwa N,Nerbonne JM.Molecular determinants of cardiac transient outward potassium current(I(to))expression and regulation[J].J Mol Cell Cardiol,2010,48(1):12-25.
[6]Li G,Cheng G,Wu J,et al.Drug-induced long QT syndrome in women[J].Adv Ther,2013,30(9):793-802.
[7]王观青,严干新,崔长琮.J波综合征[J].实用诊断与治疗杂志,2008,22(5):360-362.
[8]裴娟慧,浦介麟.J波综合征[J].心血管病学进展,2011,32(4):483-486.
[9]Antzelevitch C,Yan GX.J wave syndromes[J].Heart Rhythm,2010,7(4):549-558.
[10]崔长琮,严干新.急性缺血性J波和J波综合征的研究现状[J].中华心血管病杂志,2010,38(4):299-300.
[11]洪葵,熊琴梅.Brugada综合征:临床和分子生物学研究进展[J].心血管病学进展,2010,31(1):13-16.
[12]狄梦阳,白融.药物性Brugada样心电图-综合征[J].心血管病学进展,2010,31(4):501-504.
[13]王龙,赵菁,王伟民,等.右冠状动脉圆锥支痉挛出现Ⅰ型Brugada样心电图改变1例[J].中华心血管病杂志,2010,38(2):181-182.
[14]Brugada P,Brugada J.Right bundle branchblock,persistent STsegment elevation and sudden cardiac death:a distinct clinical and electrocardiographic syndrome.Amulticenterreport[J].J Am Col Cardiol,1992,20(6):1391-1396.
[15]王军,杨钧国,张守焰,等.Brugada综合征和特发性J波的临床分析[J].中华心律失常学杂志,2001,5(6):351-354.
[16]Kapplinger JD,Tester DJ,Alders M,et al An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing[J].Heart Rhythm,2010,7(1):33-46.
[17]彭颖秀.J波综合征的临床探讨[J].现代中西医结合杂志,2011,34(20):4348-4350.
[18]Yan GX,Lankipalli RS,Burke JF,et al.Ventricular repolarization components on the electrocardiogram:cellular basis and clinical significance[J].J Am Coll Cardiol,2003,42(3):401-409.
[19]Bayés de Luna A,Brugada J,Baranchuk A,et al.Current electrocardiographic criteria for diagnosis of Brugada pattern:a consensus report[J].J Electrocardiol,2012,45(5):433-442.
[20]Jastrzabski M,Kukla P.Ischemic J wave:novel risk marker for ventricular fibrillation?[J].Heart Rhythm,2009,6(6):829-835.
[21]宁爱民.Brugada综合征及其临床进展[J].心电学杂志,2004,23(4):247-253.
[22]Carrado D,Nava A,Buja G,et al.Familial cardiomyopathy underlies syndrome of right bundlebranch block,ST segment elevation and sudden death[J].J Am Coll Cardiol,1996,27(2):443-448.
[23]张清华.Brugada综合征临床处理的当今观点[J].临床心电学杂志,2003,12(3):147.
[24]何梅先,宿燕岗,刘学波,等.植入型转复除颤器治疗Brugada综合征3例[J].中华心律失常学杂志,2002,6(1):56.
[25]Shipleygn RA,Hallaran WR.The four lead electrocardrogram in200 normal men and women[J].Am Heart J,1936,11:325-345.
[26]李华,刘艳.早复临床20例分析[J].中国医师杂志,2004,6(2):235.
[27]Di Diego JM,Cordeiro JM,Goodrow RJ,et al.Ionic and cellular bassis for the predominance of the Brugada syndrome phenotype in males[J].Circulation,2002,106(15):2004-2011.
[28]Wolpert C,Veltmann C,Schimpf R,et al.Is a narrow and tall QRScomplex an ECG marker forsudden death?[J].Heart Rhythm,2008,5(9):1339-1345.
[29]Boineau JP.The early repolarization variant--an electrocardiographic enigma with both QRS and J-STT anomalies[J].J Electrocardiol,2007,40(1):3.
[30]Nam GB,Ko KH,Kim J,et al.Mode of onset of ventricular fibrillation in patients with early repolarization pattern vs.Brugada syndrome[J].Eur Heart J,2010,31(3):330-339.
[31]Derval N,Simpson CS,Birnie DH,et al.Prevalence and characteristics of early repolarization in the CASPER registry:cardiac arrest survivors with preserved ejection fraction registry[J].J Am Coll Cardiol,2011,58(7):722-728.
[32]Rosso R,Adler A,Halkin A,et al.Risk of sudden among young individuals with J waves and early repolarization:putting the evidence into perspective[J].Heart Rhythm,2011,8(6):923-929.
[33]Haissaguerre M,Derval N,Sacher F,et al.Sudden cardiac arrest associated with early replarization[J].N Engl J Med,2008,358(19):2016-2023.
[34]Rosso R,Kogan E,Belhassen B,et al.J-point elevation in survivors of primary ventricular fibrillation and matched control subjects:incidence and clinical significance[J].J Am Coll Cardiol,2008,52(15):1231-1238.
[35]Yan GX,Antzelevith C.Cellular basis for electrocardiographic Jwave[J].Circulation,1996,93(2):372-379.
[36]Otto CM,Tauxe RV,Cobb LA,et al.Ventricular fibrillation causes sudden death in Southeast Asian immigrants[J].Ann Intern Med,1984,101(1):45-47.
[37]Kalla H,Yan GX,Marinchak R.Ventricular fibrillation in a patient with prominent J(Osborn)waves and ST segment elevation in the inferior electrocardiographic leads:a Brugada syndrome variant?[J].J Cardiovasc Electrophysiol,2000,11(1):95-98.
[38]Nademanee K,Veerakul G,Chandanamattha P,et al.Prevention of ventricular fibrillation episodes in Brugada syndrome by catheter ablation over the anterior right ventricular outflow tract epicardium[J].Circulation,2011,123(12):1270-1279.
[39]Di Diego JM,Antzelevitch C.Cellular basis for ST-segment changes observed during ischemia[J].J Electrocardiol,2003,36 Suppl:1-5.
[40]封盼攀,马康华.缺血性J波和恶性心律失常[J].心血管病学进展,2011,32(2):188-190.
[41]许彩娜,刘宽芝,王战建.应激性高血糖与急性冠脉综合征[J].河北医药,2008,30(3):362.
[42]Libby P,Ridkei PM,Hansson GK,et al.Inflammation in atherosclerosis:from pathophysiology to practice[J].J Am Coll Cardiol,2009,54(23):2129-2138.
[43]吴蔚,杨希立,刘宇清,等.急性冠脉综合征缺血性J波的临床意义[J].临床心电学杂志,2013,22(4):254-255.
[44]谢玲斐,黄伟剑,张怀勤,等.含缺血性J波的急性冠脉综合征不同治疗方法的预后探讨[J].现代实用医学,2009,3(2):893-895.