摘要
目的:观察平消胶囊联合FOLFIRI化疗方案(CPT-11+5-FU+CF)治疗晚期结直肠癌的疗效及毒副反应。方法:自2008年5月至2010年02月在新疆维吾尔自治区中医院肿瘤科住院病例,选应用平消胶囊联合FOLFIRI化疗方案治疗晚期结直肠癌患者33例与单纯行FOLFIRI化疗方案的晚期结直肠癌患者30例行随机对照试验。FOLFIRI化疗方案为:伊立替康(CPT-11)+5-氟尿嘧啶(5-FU)+亚叶酸钙(CF)。33例晚期结直肠癌患者自化疗之日起即口服平消胶囊(西安正大制药有限公司生产,0.23g/粒),口服,1.84g/粒,3次/日,IFL化疗方案的应用方法:伊立替康150mg/m2加入0.9%氯化纳注射液250mL中静脉滴注,第1天;5-氟尿嘧啶400mg/m2静脉推注,再用5-氟尿嘧啶600mg/m2通过全自动注药泵持续静脉输注22h,第1、2天;亚叶酸钙200mg/m2加入5%葡萄糖注射液250mL中静脉滴注,第1、2天。14d为1个周期,2周期为1个疗程。治疗前后观察患者食欲、疼痛缓解情况、疲乏改善程度,以及血常规、肝肾功及心电图等相关检查指标的变化情况。结果:平消胶囊联合FOLFIRI化疗可改善大肠癌患者部分临床症状,缓解疲乏状态,提高生活质量,并减轻血液和消化系统毒副反应,与对照组相比,P<0.05,有统计学意义,两组对肝、肾功能的损害不明显,P>0.05,无统计学意义。结论:平消胶囊作为纯中药制剂,有活血化瘀、散结止痛、扶正祛邪、清热解毒之功效,且联合FOLFIRI化疗方案作为治疗组在治疗晚期结直肠癌时在一定程度上能够提高化疗疗效,并能保护和促进骨髓造血功能,减轻血液学毒性,值得临床应用。
Objective:To observe the effect and toxicity of the regimen of Pingxiao capsule combined with chemotherapy scheme of FOLFIRI for the treatment of advanced colorectal Cancer. Methods:Choosing the patients be hospitalized in our hospital between May,2008 and February,2010. Pingxiao capsule plus chemotherapy scheme of FOLFIRI was applied to treat 33 cases of advanced colorectal Cancer and choosing 30 patients for the only chemotherapy scheme of FOLFIRI. chemotherapy scheme of FOLFIRI include:CPT-11 150mg/m2 and 0.9% NaCl 250 mL ivgtt d1 5-FU 400 mg/m2 iv bolus,Following 5-FU 600 mg/m2 ivgtt 22h d1,d2;CF 200 mg/m2 and 5% GS 250mL ivgtt 2h d1,d2;two weeks as one cycle,efficacy and toxicity were evaluated at three cycles. When beginning the chemotherapy scheme of FOLFIRI,the group of curing patients take the medicine of Pingxiao capsule until the treatment being end. In front and behind,to observe the situation of the,appetite,extent of pain and tiring,the target of liver and kidney function,blood routine,ECG. Results:After two periods of treatment,the subjective symptoms、KPS、weights、the tumor mark(CEA)were significantly improved in the treated group,better than in the control one. In the sides of curative effect and quality of living,even the degree of alimentary canal side-effect and hematology toxicity in treatment group were better than the control group,P<0.05. But there was no difference between two groups on the size of focus,the toxicity occurent rate and toxic degree ware slighter in the treated group than in the control one,P>0.05.Conclusion:Pingxiao capsule combined with chemotherapy for the treatment of advanced colorectal Cancer can alleviate the alimentary cancal side-effect and hematology toxicity of chemotherapy drug in treating gastric cardia carcinoma.In all,it is effective and tolerable in advanced colorectal cancer. It is good for generalizing.
引文
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