三维数据场虚拟内窥镜技术研究
详细信息    本馆镜像全文|  推荐本文 |  |   获取CNKI官网全文
摘要
虚拟内窥镜技术是当前虚拟可视化研究的一个重点,是计算机技术、计算机图形学、计算机图像处理以及虚拟现实技术应用于医学内窥镜系统而形成的一种独特的技术。虚拟内窥镜是近几年出现的医学图像高级后处理系统,由于它是一种非侵入型、无接触式的零创伤医疗检查手段,使得它在诊断医学和解剖教学领域中的应用越来越广泛。
     本文针对虚拟内窥镜系统的关键技术和实现方法进行了系统深入的研究。首先,研究了医学图像的分割标注技术,提出了一种感兴趣区域(ROI)的快速模糊分割算法,在保持高精度的情况下实现了ROI的快速分割;其次,针对医学图像体数据边缘模糊的问题,提出了一种基于二维直方图的交互式三维边缘增强算法,使得体数据可以进行交互式边缘增强,方便用户跟踪分析感兴趣的内容;在虚拟内窥镜系统的研究中,提出了一种改进的基于区域增长技术的自动漫游路径提取算法;同时针对表面重建的伪影问题,提出了一种基于各向异性的平滑算法,使得内窥效果更加逼真;最后,通过分析虚拟内窥镜和体数据可视化方法的特点,提出了一种基于混合体绘制的虚拟内窥镜算法,进一步提高了虚拟内窥镜系统的逼真效果。
Virtual endoscopy is a hot research topic in the field of scientific visualization, which unique technique is an important application of computer, computer graphics, image processing and virtual reality in endoscopy system. It is a advanced medical image post-processing system emerging only several years ago. Since it is a non-invaded, non-touched means and non-hurt examination method, virtual endoscopy is widely used in diagnostic and teaching in anatomy recently.
    Some key techniques and realizations of virtual endoscopy are systematically investigated in this thesis. Firstly, for the medical image segmentation problem, a fast fuzzy c-means (FCM) segmentation algorithm is proposed for the region-of-interest (ROI). Secondly, an interactive 2D histogram segmentation algorithm for interactively segmenting 3D data is also proposed. With this fast interactive segmentation method, scientists can study the interesting parts conveniently. Thirdly, the interactive virtual endoscopy techniques are investigated, and an automatics wandering fashion in virtual endoscopy system implemented. For the false contour problem of the surface rendering, an anisotropic diffusion smoothing algorithm is presented for surface blur. Finally, by analyzing the characteristic virtual endoscopy and volume data virtualization, an integrated volume virtual endoscopy algorithm is proposed to further improve the vivid effect of the virtual endoscopy system.
引文
[01] Duffner F, Dauber W, Skalej Metal. A New endoscopic tool for the CRW stereotactic System. Stereotatic and Functional Neurosurgery, 1994, 67(3~4):213~217.
    [02] D. J. Vining. Virtual endoscopy. Gastrointest Endoscopy Clinic application. 1997, 7. 285~291.
    [03] L. Hong, A. Kaufman et al. 3D virtual colonoscopy. IEEE symposium on Biomedical Visualization. 1995,1.26-32.
    [04] Vining D., Gelfand D., Bechtold R. Technical feasibility of colon imaging with helical CT and virtual reality. Annual Meeting of American Roentgen Society, New Orleans LA. April, 1994: 104.
    [05] 李乃弘,于文雪等.三维人体虚拟内窥镜的实验研究.航天医学与医学工程.1999(12).209-213.
    [06] W. Lorensen, E jolesz. The Exploration of cross-sectional data with a virtual endoscopy. Interactive Technology and New Medical Paradigms for Health Care. Amsterdam: IOS Press. 1995.
    [07] 张惠,舒华忠等.交互式虚拟内窥镜系统.中国图像图形学报.2002,7(1).36-43.
    [08] Keppel E. Approximating complex surfaces by triangulation of contour lines. IBM J. Res. Dev. 19, 1975.
    [09] J. K. Udupa, D. Odhner. Fast visualization manipulation and analysis of binary volumetric object. IEEE CG&A, 1991, 13(12): 55-60.
    [10] S. Muraki. Volume data and vavelet transform. IEEE CG&A, 1993, 13(4): 20-30.
    [11] T. Malzbender. Fourier volume rendering. ACM Trans. Graphics. 1993, 4(3): 30-35.
    [12] 钟世镇.我国数字化虚拟人体研究现状和对策.http://academy2003.cpst.net.cn/popul/academy/artic/30914133100.html.
    [13] 罗述谦.数字化虚拟人图像处理及设想.香山科学会议第208次学术讨论会.
    [14] Martin L.Brady, Kenneth K.Jung, et al. Interactive volume navigation. IEEE Transactions on Visualizationg and Computer Graphics, Vol.4, No.3, July, 1998.
    [15] Jocha D. Koloszár, J. Virtual colonoscopy using direct volume rendering of surfaces from volumetric data. KEPAF 2002, Hungary, 2002.
    
    
    [16] G.T. Herman, H. K. Liu. Three-dimensional display of human organs from computed tomograms. Computer Graphics Image Processing. Vol.9, 1979.
    [17] 管伟光.体数据可视化极其在医学中的应用.中国科学院自动化研究所博士论文,1995.
    [18] J. Wilhelms, et al. Topological considerations in isosurface generation. San Diego Workshop on Volume Visualization, 1991.
    [19] Lorensen W. E. and Cline H. E. Marching cubes: a high resolution 3D surface construction algorithm. Compute Graphics, 1987, 21 (4): 163-9.
    [20] H.E.Cline, et al. Two algorithms for three-dimensional reconstruction of tomograms. Med. Phys. Vol.15, No.3, 1988.
    [21] M.J. Durst. Letters: Additional reference to "marching cubes". Computer Graphics, Vol. 22(2). 1988.
    [22] Doi, A. Koide. An Efficient method of triangulating Euqi-valued surfaces by using tetrahedral cells. IEICE Transactions, E74 (1), 214-224, 199.
    [23] 周勇,唐泽圣.用自适应的三线性逼近方法构造等值面.计算机学报,17(增刊),1-10,1994.
    [24] 唐泽圣 等.三维数据场可视化.清华大学出版社.1999.12.
    [25] L.Westover. Footprint evaluation for volume rendering. Computer Graphics. Vol.24, No.4, 1990.
    [26] Kenneth R.Hoffmann, Zhan Zhang. Visualization and navigation techniques in CT colonography. Visualization and Navigation Techniques in CT Colonography. 2001, 10, 3.
    [27] Tong-Yee Lee, Ping-Hsien Lin, Chao-Hung Lin, Yung-Nien Sun, and Xi-Zhang Lin. Interactive 3-D virtual colonoscopy system. IEEE Transactions on Information Technology in Biomedicine, Vol.3, No.2, June 1999.
    [28] Lichan Hong, Shigeru Muraki, Arie Kaufman, Dirk Bartz, and Taosong He. Vitrual voyage: interactive navigation in the human colon. Computer Graphics (Proceedings of Siggraph'97), 27-34, Los Angeles, 1997.
    [29] 耿国华,周明全.交互式实时虚拟内窥镜系统中的关键技术.计算机应用Vol.22,No.11,54-55.
    [30] 范江波,周明全,耿国华.虚拟内窥镜技术的研究与实现.微机发展,2000(6),60-62.
    [31] Anne Verroust, Francis Lazarus. Extracting skeletal curves from 3D scattered data. Shape Modeling International'99, Aizu Wakamatsu, March 1-4, 1999.
    [32] W. Niblack, P.B. Gibbons, D. Capson. Generating skeletons and centerlines from
    
    the distance transform. CVGIP: Graphical Models Image Processing. 1992, 128.420-437.
    [33] Goshtasby, A. Turner, D.A. Segmentation of cardiac cine MR images for extraction of right and left ventricular chambers. IEEE Transactions on Medical Imaging,1995,14(1):56~64.
    [34] Thedens, D.R., Skorton D. J., Fleagle, S.R. Methods of graph searching for border detection in image sequence with application to cardiac magnetic resonance imaging. IEEE Transactions on Medical Imaging, 1995,14(1):42~55.
    [35] 李燕,潭鸥,段会龙.三维医学可视化技术综述.中国图像图形学报,2001,2.
    [36] John F. Kolen Tim Hutcheson. Reducing the time complexity of the fuzzy C-means algorithm. IEEE Transaction on Fuzzy Systems, 10(2): 10(2), 2002.
    [37] Chen Changwen et al. Knowledge-based approach to volumetric medical image segmentation. IEEE International Conference on Image Processing Los Alamitos, USA: IEEE, 1994,3:493-497.
    [38] 高新波,模糊聚类算法的优化及应用研究,西安电子科技大学博士学位论文,1998,3.
    [39] 丁震,胡钟山等.一种用于灰度图像分割的快速FCM算法,电子学报,1997,10(6):133-137.
    [40] Steven Eschrich, Jingwei Ke. Fast fuzzy cluster of infrared images. Technical Report, University of South Florida, 2001.
    [41] Chen W. T. Wen C. H. Yang C.W. A Fast two-dimension entropic thresholding algorithm. Pattern Recognition, 1994, 27:885-893.
    [42] 景晓军,蔡安妮,孙景鳌.一种基于二维最大类间方差的图像分割方法.通讯学报,2001(4):71-76.
    [43] Zhengrong Liang, Mark R. Wax, Lihong Li. et al. A Novel approach to extract colon lumen from CT image for virtual colonoscopy. IEEE Trans. on Medical Imaging. Vol. 1, No. 12, December 2000.
    [44] G.D. Rubin et al. Perspective volume rendering of CT and MR image: application for endoscopic viewing. Radiology. 1996, 199: 321-330.
    [45] R. Wegenkittl, A. Vilanova, B. Hegedus, D. Wagner, M. C. Freund, and E. M.Groller. Mastering interactive virtual bronchioscopy on a low-end pc. In Proc. of IEEE Visualization 2000, 461-464.
    [47] H.E.Cline, W.Lorensen, et al. Two algorithm for three-dimensional reconstruction of tomograms. Medical Physics. 1988, 15(3). 3-20.
    [48] G. J. Jensc, D. P. Huijsmans. Interactive voxel-based graphics for 3D
    
    reconstruction of biological structure. Computer Graphics. 1989, 13(2). 19-89.
    [49] A. Wallin. Constructing isosurface from CT data. IEEE CG&A. 1991, Nov.
    [50] E. Keppel. Approximating complex surface by triangulation of contour lines. IBM J. Res. 1975, 19.
    [51] L. Weiss. 3D shape representation by contours. CVGIP. 1988, 41.33-53.
    [52] H. Hoppe. Mesh optimization. SIGGRAPH93.1993, 1.23-26.
    [53] Lee T.Y., Weng T.L., Lin C.H., Sun Y.N., Interactive Voxel surface rendering in medical applications. Computerized Medical Imaging and Graphics, 23, 1999: 193-200.
    [54] G. T. Herman. H. K. Liu. Three-dimention display of human organs from computed tomograms. Computer Graphics Image Processing. Vol.9. 1979.
    [55] M. Sato, S. Lakare, M. Wan, A. Kaufman, Z. Liang, and M. Wax. An Automatic colon segmentation for 3D virtual colonoscopy. IEICE Trans. Information and Systems, Vol. E84-D, No. 1, January 2001, 201-208.
    [56] K. Hohne, R. Berstein. Shading 3D image from CT using gray level gradients. IEEE Trans. on Medical Imaging. 1986, 5(1): 15-26.
    [57] Claussen Seemann. Hybrid 3D visualization of the chest and virtual endoscopy of the tracheobronchial system: Possibilities and limitations of clinical applications. Lung Cancer, 32(3): 237-46, 2001.
    [58] S. Dogramadzi, C. R. Allen, and G. D. Bell. Computer controlled colonoscopy. IEEE Instrumentation and Measurement Technology Conference, 210-213, May, 1998.
    [59] Enrico Gobbetti, Piero Pili, Antonio Zorcolo, and Massimiliano Tuveri. Interactive virtual endoscopy, http://www.crs4.it
    [60] R. Hietala, J. Oikarinen. A Visibility determination algorithm for interactive virtual endoscopy. In Proc. of IEEE Visualization 2000, 29-36.
    [61] Daniel Wanger, Rainer Wegenkittl, and Eduard Groller. Endoview: a phantom study of a tracked virtual bronchoscopy, http://www.google.com
    [62] Aly A. Farag Charles B. Sites. Virtual endoscopy: modeling the navigation in 3D brain volumes, http://www.google.com.
    [63] 张先勇,郝重阳,淮永建.远程交互式虚拟内窥镜系统.计算机工程.Vol.28(11),2002.
    [64] P. Perona J. Malik. Scale space and edge detection using anisotropic diffusion. IEEE Trans. on Pattern Analysis and Machine Intelligence, 12(7): 629-639, July 1990.
    
    
    [65] 西安盈谷科技有限公司.三维图像处理技术文档.www.accurad.com
    [66] T. Saito, J. Toriwaki. New algorithms for euclidian distance transformation of an N-dimensional digitized picture with applications. Pattern Recognition. Vol.27, 1551-1565, 1994.
    [67] S.Wood, E.Zerhouni, J. Hoford, E. Hoffman. Measurement of three-dimensional lung structures by using computed tomography. Apply Physiology. 1995, 79. 1687-1697.
    [68] D. Blezek, R. Robb. Centerline algorithm for virtual endoscopy based on chamfer distance transform and Dijkstra's single source shortest path. Proceedings of SPIE. 1999, 3660. 225-233.
    [69] Krissian, K., Malandian, G., Ayache, N. Directional anisotropic diffusion applied to segmentation of vessels in 3D images. Proceedings of the first International Conference on Scale-Space Theory in Computer Vision., Scale-Space '97.
    [70] Koloszar J., Jocha, D. Accelerating volumetric ray tracing in virtual endoscopy. First Hungarian National Conference on Computer Graphics, 2002.
    [71] M. Levoy, A Hybrid ray tracer for rendering polygon and volume data. IEEE CG. & A., 10(2): 33-40, 1990.
    [72] D. S. Ebert, R. E. Parent. Rendering and animation of gaseous phenomena by combining fast volume and scan-line a-buffer techniques. Computer Graphics, 24(4): 357-366, 1990.
    [73] M. Fruhauf. Combining volume rendering with line and surface rendering. Proceedings of EUROGRAPHICS'91, Elsevier Science Publishers, p21-32, 1991.
    [74] A. Rosenfeld, A.C. Kak. Digital Picture Processing. Academic Press. 1982.
    [75] 徐建华.图像处理与分析.科学出版社,1982.
    [76] Cabral B, Cam N, Foran J. Accelerated volume rendering and tomographic reconstruction using texture mapping hardware[A]. Spencer S. Proceedings of ACM Symposium on Volume Visualization[C]. Washington: ACM Press. 1994, 91-98.
    [77] H. H. Ehricke., G. Daiber., And W. Straber. The Vision camera: an interactive tool for volume data exploration and navigation. Visualization '93.
    [78] 周礼平,高新波.图像分割的快速模糊均值聚类算法,计算机工程与应用(已录用).
    [79] 王刚,交互式虚拟内窥镜系统研究,西安电子科技大学硕士论文,2003,1.
    [80] 沈傲东,医学影像三维重建方法研究,西安电子科技大学硕士论文,2003,1.