肝经取穴为主治疗血瘀型单纯性肥胖的临床研究
详细信息    本馆镜像全文|  推荐本文 |  |   获取CNKI官网全文
摘要
单纯性肥胖是指无明显病因可循的体内脂肪堆积过多,体质量增加或脂肪分布异常,以肥胖为主要临床症状,可伴有代谢异常表现,主要由遗传及不良生活方式造成,占肥胖人群中的多数。它与高血压、冠心病、糖尿病、脑血管意外等疾病密切相关。治疗单纯性肥胖的重点在于长期控制体重,而不是在短期内快速减轻体重。在众多的治疗方法中,针灸疗法能调节食欲,恢复自主神经平衡指数,符合国际减肥不厌食、不腹泻、降低体重而不降低体力的原则。
     第一部分:文献探讨
     社会的发展使更多的人趋向于多食少动,焦虑紧张,生活无规律,易导致肝郁气结,肝脾不和,不能疏理气机、调畅血液,不能升清降浊,使体内瘀浊膏脂停留而为血瘀型肥胖。肥胖者血液表现出浓、粘、聚、凝的特点,肥胖与血瘀相互影响,互为因果。肝经穴位大多能理气活血、通淋消肿、调经止痛,推断肝经取穴为主治疗肥胖能改善患者血瘀体质,减轻体重,治疗情绪失调、月经不调、局部疼痛等并发症,降低继发心脑血管病、癌症等重大疾病的风险。
     第二部分:临床研究
     目的:观察肝经和胃经选穴对血瘀型单纯性肥胖的疗效差异,探讨其原因,总结血瘀型单纯性肥胖的选穴治疗规律。
     方法:本研究收集血瘀型单纯性肥胖患者60例,随机分胃经组、肝经组各30例,两组均使用目前国内针灸减肥最为常用的中脘、天枢、足三里、丰隆等穴,胃经治疗组加滑肉门、外陵、水道、梁丘、上巨虚、内庭等穴位,肝经治疗组加期门、章门、曲泉、蠡沟、太冲、肝俞、膈俞等穴位,留针加电,同时腹部照射TCD红外线灯,每次30分钟,每周治疗3次,15次为一疗程,一个疗程结束后,间隔7天再开始第二个疗程,两个疗程完成后对比治疗前后各组肥胖指标、血液流变学指标、症状评分等变化。
     结果:肝经组与胃经组均取得一定的疗效,肝经组总有效率为86.7%,胃经组总有效率为63.3%,肝经组疗效优于胃经组(P<0.05)。肝经组在降低体重、BMI方面,与胃经组相比有显著性差异(P<0.05);在降低腰臀比方面差异无显著性(P>0.05),在改善血液流变学指标及部分血液成份方面,肝经组效果明显优于胃经组(P<0.05),对血瘀型肥胖的主要临床症状如皮肤粘膜色黑、月经不调、局部疼痛等,肝经组疗效明显优于胃经组(P<0.01)。
     结论:肝体阴而用阳,能疏调气血、调畅情志,肝经虽为阴经,同时也体现出“阳”的作用,取其经穴治疗可泄浊散邪、助脾散精、疏利三焦水道等,达到瘀浊膏脂水饮自散,肥胖消除的目的。运用此法治疗血瘀型肥胖,不但可兼顾标本,且经济方便,疗效确切,值得深入研究以推广运用。
Simple obesity and overweight is defined as abnormal or excessive fat accumulation of unknown aetiology that presents a risk to health. Usually, it is accompanied by other symptoms of metabolic disorder. Obesity can occur for many reasons, the main two are unhealthy lifestyle habits and genetic inheritance. Being overweight or obese increases the risk of many diseases and health conditions, such as hypertension, coronary artery disease, diabetes mellitus and stroke. The therapy of simple obesity should focus on long-term control of body weight instead of decreasing the body weight rapidly in short term. Based on the principles of obesity prevention which are reducing weight without hyposthenia, diet without anorexia and diarrheal, acupuncture therapy provides effective impact on body weight reduction by adjusting appetite and balancing autonomic nerves. Therefore, the research of acupuncture therapy is valuated.
     Background: With rapid development of human society, the number of people who are living under high pressure and being anxiety is increased. Many people are experiencing overeating and lack of exercises. All of these factors form an unhealthy lifestyle. Using the theories of TCM as framework, unhealthy lifestyle causes stasis of the liver Qi and disharmony between the liver and the spleen, as a result of that, the Qi and blood of the body cannot circulate smoothly, then the fat will accumulate in the body gradually, and the blood-stasis syndrome will be occurred. Moreover, the blood of the obesity patients will become viscous, thicker and the blood flow will be slow and static. It shows that the relationship between obesity and blood-stasis is interrelated. In TCM theories, blood stasis can be treated by adjusting Qi and blood of the liver. Most acu-points of the liver meridian can help the Qi and blood circulate smoothly, induce diuresis to alleviate edema, regulate menses and alley pain. So, we suggest that choosing the acu-points of the liver meridian can treat obesity, can improve the patient's blood-stasis constitution, reduce body weight, adjust emotion, regulate menses, alley pain, and reduce the risk of diseases of the heart, brain and blood vessels.
     Objective: To evaluate the effect and probe into the mechanism of choosing the acu-points of the liver meridian to treat simple obesity with blood-stasis syndrome.
     Methods: 60 cases of simple obesity with blood-stasis syndrome were randomly divided into two groups—stomach meridian (SM) group and liver meridian (LM) group. Both groups accepted the most frequently-used acu-points in weight reduction, such as ZhongWan, TianShu, ZuSanLi and FengLong, and infared lamp irradiation on belly as a basic treatment. Additionally, SM group accepted the acu-points of stomach meridian, such as HuaRouMen, WaiLing, Suidao, LiangQiu, ShangJuXu, FengLong, and NeiTing; LM group accepted the acu-points of liver meridian, such as QiMen, ZhangMen, QuQuan, LiGou, TaiChong and Ganshu, Geshu. All these treatments were given 3 times (30 minutes per time) a week, and 5 weeks as one period of treatment. Two periods of treatment with a 7-day interval were given totally. The score of symptoms were marked and the indexes of obesity and hemorheology were measured before and after all the treatments.
     Results: Total effective rate of the LM group was 86. 7%, much higher than the GM group which was 63.3% (p<0.05). The effects of the LM group on weight reduction, improvement of BMI and hemorheology were superior to the GM group (p<0.05). And the alleviation of the symptoms in the LM group was more remarkable than the GM group (p<0. 01). But the waist-to-hip ratio of both groups had no statistic difference (p>0.05).
     Conclusions: Using the acu-points of the liver meridian has remarkable effects on treating simple obesity with blood-stasis syndrome. This treatment can improve the patient's blood-stasis constitution, reduce body weight, regulate menses and alley pain. Those effects are due to the liver meridian function of smoothing Qi and blood.
引文
[1]徐业,石现洲,梁迪赛.肥胖症的现代研究进展及对策 江西中医学院学报 2005,17(5):78
    [2]黄琴峰,王正明,齐丽珍.建国以来针灸治疗肥胖病述评[J].上海针灸杂志,2006,25(2):40
    [3]候凌,罗小平.肥胖及相关基因[J].中国实用儿科杂志,2004,19(3):144
    [4]武阳丰,周北凡,陶寿淇,等.我国中年人群超重率和肥胖率的现状及发展趋势[J].中华流行病学杂志,2002,23(1):11
    [5]Piez JJ,Iglesias P·The role of the novel adipocyte-derived hormone adiponection in human disease[J].Eur J Endocrinol,2003,146:293
    [6]Steppan CM,Bailey ST,Bhat S,et al·The hormone resistin linksobesity to diabetes[J].Nature,2001,409:307
    [7]Fuhbesck G,Gomez-Ambrosi J,Muruzabal FJ,et al·The adipocyte:a model for integration of endocrine and metabolic signaling in ener-gy metabolisn regulation[J].Am J physiol Endocinol Metab,2001,280:E827
    [8]Boden G.Role of fatty acids in the pathogenesis of insulin resistance and NIDDM[J]·Diabetes,1997,46:3
    [9]黄传宇,刘玉芳.肥胖与高尿酸症关系的调查研究[J].中华综合医学,2003,4(2):128
    [10]VISSER M,BOUTER L M,McQUILLAN G M,et,al·Elevated C-reative protein overweight and obese adults[J].JAMA,1999,282(22):2 131
    [11]Hashimoto M,Akishita M,Eto M,et al·The impairment of flow-mediated,Vasotilatation in odese men with visceral fat accumulation[J].Int J Obes Relat Metab Disord,1998,22:477
    [12]焦付丰,陈振祥,张春雷.超重及肥胖者凝血、抗凝血、纤溶指标变化的意义[J]。检验医学,2004,19(2):109
    [13]Bergman RN,Van Citters GW,Mittelman SD,et al·Gentral role ofthe adipocyte in themetabolic syndrome[J].J Invest Med,2001,49:119
    [14]刘煜.病毒与肥胖[J].国外医学-内分泌分册,2002,22(30:172
    [15]刘志诚,孙凤岷,申冬珠,等.从植物神经功能和血浆环核苷酸含量的变化研究针灸减肥作用[J].中西医结合杂志,1991,11(2):83
    [16]Liu Zhicheng,Li Jia,Shi Xiaopo,et al.Acupuncture for patients with simple obsity[J].Int J of Clin Acup,1991,2(2):109
    [17]Sun Fengmin,Liu Zhicheng,LiuZhou.Effect of acupuncture oncaloric intake of patients with simple obsity[J].Int J of Clin Acup,1994,5(4):379
    [18]Sun Fengmin,Liu Zhicheng,Zhu Miaohua,et al.Effect ofacupuncture on energy metabolism in simple obesity[J].Int J of Clin Acup,1997,8(2):123
    [19]刘志诚,张京英.针刺对单纯性肥胖患者外周5-羟色胺代谢的作用[J].上海针灸杂志,1990,9(2):1
    [20]刘志诚,孙凤岷,王沂争,等.针刺治疗对单纯性肥胖病胃肠实热型患者的良性调整作用探讨[J].中西医结合杂志,1995,15(3):137
    [21]刘志诚,沈海红,魏群利,等.针灸对单纯性肥胖症胰岛素抵抗的作用[J].江苏中医,1999专辑:8
    [22]刘志诚,孙凤岷,胡葵.针灸为主治疗单纯性肥胖患者的临床研究[J].上海针灸杂志,1997,1(1):6
    [23]孙凤岷,刘志诚.针灸减肥及其对水盐代谢的影响[J].针刺研究,1996(2):19-23
    [24]杨颖.自拟减肥8穴配合耳穴贴压治疗单纯性肥胖病临床观察[J].河北中医,2005,27(5):366
    [25]乔子虹,雷红.腹部电针治疗单纯性肥胖47例.中国针灸[J],2005,25(1):671
    [26]Lin Hong.Treatment of 90 cases of Simple Obesity with Intermuscular Needling.Met hod.JoUrnal of Acupuncture and Tuina Scince,2006,4(1):35-36
    [27]曾洪玉.针灸治疗单纯性肥胖的体会[J].针灸临床杂志,2005,21(3):26
    [28]项琼瑶,傅莉萍.群针术加耳穴贴压对非肥胖女性体重和体重指数的影响[J]上海中医药杂志2005,39(8):35
    [29]熊芳丽,崔瑾,宁友.腰腹群针法配合远端取穴治疗单纯性肥胖病的疗效及其分子生物学作用机制的研究[J]上海针灸杂志,2005,24(8):8-10
    [30]王新华.瘀血 人民卫生出版社 出版地:北京 出版日期:2001:34
    [31]王若光,尤昭玲.试析血瘀形成及现代研究对血瘀认识的深化 中国中医药科技2001,8(4):272
    [32]郑瑞璋,吴若銮,陈一鸣.心脑宁胶囊抗栓作用血流变的实验与临床研究[J].新中医,1997,29(2):32.
    [33]郑瑞璋,杨志忠,吴若銮.心脑宁提取液体外抗血小板聚集 临床研究新中医2000,(4):31
    [34]吴玉生,张富霞,李士林,张道杰..血瘀证血细胞参数与血液流变学指标的相关性研究.安徽中医学院学报,1996,15(6):51
    [35]施赛珠,石志芸,陈剑秋,等.血瘀证与血小板活化的关联研究[J].中国中医基础医学杂志,1996,2(4):22.
    [36]叶向荣.益气活血与理气活血对血瘀证大鼠血小板5-羟色胺、丙二醛和血浆血栓素及6-酮-前列腺素的影响[J].山东中医药大学学报,1997,21(1):76-77.
    [37]徐西,廖家桢,王硕仁.310例血瘀证患者血小板功能与中医辨证关系的临床研究中国中西医结合杂志1993,12:4
    [38]蔡钦朝.血瘀证患者血管内皮内分泌功能的观察[J].安徽中医学院学报,1998,17(2):61-63.
    [39]谢林等.丹紫康膝冲剂对膝关节退行性骨关节病患者氧自由基代谢的影响,中国中医骨伤科1996:4(2):8
    [40]袁肇凯.气滞血瘀与气虚血瘀辨证微观指标的观察分析[J].中医杂志,1995,36(9):557.
    [41]有地滋.一贯堂医学在现代医学中的价值.国外医学·中医中药分册,1986,8(4):22-24
    [42]有地滋.中国和日本医学文献中的瘀血(三).国外医学·中医中药分册,1985,7(5):18-21
    [43]邵致格,胡曼曹,王长松.现代人群的体质病理学特征:气虚血瘀.医学与哲学2005,26(4):74
    [44]何裕民,王莉,石凤亭,等.体质的聚类研究.中国中医基础医学杂志,1996,2(5):7-9
    [45]王琦,叶加农.肥胖人痰湿型体质的血液流变学及甲皱微循环研究.中国中医基础医学杂志1995,1(1):54
    [46]林齐鸣,虞学军.试论兼挟体质.四川中医,2002,20(7):9-11
    [47]陈贵海.肥胖与血瘀证形成的相关性研究[J].山东中医药大学学报,2002,26(2):129
    [48]岳广欣,陈家旭,王竹风.肝主疏泄的生理学基础探讨 北京中医药大学学报2005,28(2):1
    [49]朱长庚.神经解剖学.北京:人民卫生出版社,2002:724
    [50]金益强.中医肝脏象现代研究与临床.北京:人民卫生出版社,2000.210-212
    [51]永田胜太郎.瘀血的诊断与辅酶Q10.国外医学·中医中药分册 1996:18(3):29
    [52]Otte C,Otte JM,StrodthoffD,et al.Expression of leptin and leptin receptor during the development of liver fibrosis and cirrhosis.Exp Clin Endocrinol Diabetes,2004,12(1):10-17.
    [53]胡望明,曾荔,熊苏.非酒精性脂肪性肝病患者瘦素及胰岛素抵抗的临床研究2005,10(4):45 杂志,2004,12:651
    [55]Piche T,Vandenbos F,Abakar2Mahamat A,et al.The severity of liver fi-brosis is associated with high leptin levels in chronic hepatitis C.J ViralHepati,2004,11(1):91-96.
    [56]赵文霞,张永艳,陈天朝,等.4种中药复方对大鼠脂肪肝模型胰岛素抵抗及瘦素的影响[J].郑州大学学报(医学版),2004,39(4):600-602
    [57]阚志超,李岩,邵宏,等.清脂益肝汤对非酒精性脂肪肝大鼠治疗的实验研究[J].河北医药2006,28(3):168
    [58]张知新,叶军,王琳.儿童肥胖症不同临床分型与中医辨证的相关性 中国中医药信息杂志2005,12(6):37
    [59]徐远.中医治疗代谢综合征的思路与方法[J].中医杂志,2003,44(4):301-302.
    [60]仝小林,张志远.中医对代谢综合征的认识和治疗[J].中医杂志,2002,43(9):708-709.
    [61]俞亚琴,王彬.从血瘀角度探讨2型糖尿病胰岛素抵抗[J].浙江中医杂志,2002,37(4):175-176.
    [62]梁兴伦,韩明向.胰岛素抵抗模型大鼠的中医证候研究[J].中国中西医结合杂志,2001,21(7):528
    [63]辛丽荣,云宏.针灸活血化瘀治疗体会包头医学.2000,24(1):21-23
    [64]王阶,李海霞,胡元.血瘀证量化诊断方法学研究 中国中医基础医学杂志 2006,12(9):658
    [65]夏秋.电针膻中、章门配合推拿控制糖尿病及其并发症.现代康复,2001,5(2):142-143
    [1]卢集森,王琴,刘婉师.减肥茶治疗单纯性肥胖症200例临床观察.中医药学刊,2005,12:45
    [2]苏达朝,刘婉师.《金匮要略·胸痹心痛短气病脉证治》病机及证治探讨.中医药导报,2006,10:9