摘要
近年来,脉搏波的传播与心搏出量的研究分析一直是人们研究的热点。人们通过研究分析得到了一些关于脉搏波的传播与心搏出量的理论模型,其中包括线性理论模型和非线性理论模型。一些理论已经应用到了医疗器械测量心搏出量的研制分析中,并得到了一定的认可。但是通过实验得到的真实心搏出量数据与理论模型中(医疗器械测得)的心搏出量数据存在一定的差异。这种差异必然会引起人们的疑问——理论模型与实验真实结果的差异有多大、理论模型所适用的范围和影响因素是什么以及怎么更好的表达脉搏波的传播与心搏出量的真实关系。
本文对现有的脉搏波的传播与心搏出量的线性与非线性两种理论模型进行分析,得到了这两种理论模型的特性和一些理论模型的影响因素。对于线性、非线性两种理论模型,可以通过调整不同理论模型的不同血管壁生理参数,就能够得到一系列不同的脉搏波波形和心搏出量数值。为了得到与实验心搏出量数值相近的数值,理论模型中就要设定不同的血管壁生理参数以求得与实验数值相符的数值结果。因此就要对血管壁的生理参数进行分析,研究不同血管壁取值对心搏出量数值的影响,以确定合理的血管壁生理参数的取值,得到与实验数值相符合的理论模型。
对于线性模型,研究弹性管的生理因素β0、βl的取值对脉搏波波形以及心搏出量等参数的影响。分析结果表明,β0、βl的不同数值组合能够得到相应的脉搏波波形和心搏出量等数值。同样对于非线性模型,研究得到了不同血管壁参数取值对心搏出量数值的影响关系,调整理论模型中血管壁参数的不同取值并通过与实验结果比较确定了一组较为接近实验数值的血管壁的相关参数数值,结果同人体的生理特征大致相符,为进一步的研究分析奠定了基础。
最后将两种理论模型得到的心搏出量等数值进行对比分析,分析两种理论模型与实际数值结果的差异以及造成这一结果的影响因素,并得到了一些有意义的结论。这些结论帮助人们更好的了解现有的理论模型的特性,以及不同理论的适用范围和影响因素。本文的探索性研究为进一步详尽的理论分析和理论修复奠定了基础,随着理论的进一步研究分析,脉搏波的传播与心搏出量的研究分析理论将进一步完善,并能够更加真实的反映脉搏波的传播与心搏出量的准确关系。
The pulse wave transmission and cardiac output is studied. Some linear and nonlinear models have been studied. And some models have been applied in the field of appliance of medical treatment. But the cardiac output measured by experiment is different from the cardiac output computed in the theory. These differences lead to some doubts: how many differences between the cardiac output of experiment and the methods, what is the extension of the theories, what are the factors that affect the cardiac output in the theories, and how to improve the linear and nonlinear models.
In this dissertation, the linear and nonlinear models have been studied to acquire the characteristics and the factors which affect the cardiac output in the theories. According to physiological parameters of vassal wall in both the linear and nonlinear models, the cardiac output in the proximal end of the stretch tube can be obtained by the waveform of blood pressure in the distant end of the stretch tube. To obtain close value of the cardiac output, the different values of cardiac output should be computed in the conditions of different physiological parameters of vassal wall in the linear and nonlinear models. Therefore we must to study how the physiological parameters of vassal wall affect the cardiac output in the theories and then determine the value of different physiological parameters of vassal wall.
The impact of numerical value of physiological parametersβ0、βl on the cardiac output have been studied in linear model. The results indicate that different value of physiological parametersβ0、βl can reflect different numerical values of cardiac output. The same as the nonlinear model, the impact of numerical value of different physiological parameters on the cardiac output have been studied in nonlinear model. Adjusting the numerical value of different physiological parameters and comparing numerical value of cardiac output with experiments, the close values of physiological parameters have been ascertained.
The differences between the linear model and the nonlinear model by comparing their value of cardiac output with the experimental value of cardiac output are studied. The influencing factors of the differences are studied. Finally some significant conclusions are studied. These conclusions can help us to understand the models. All the studies ahead are the bases of the farther study and will promote to perfect the models. In future study, relationship between the pulse wave and the cardiac output will be improved.
引文
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