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在“Elsevier电子期刊”中，命中：7,187条，耗时：0.0479746 秒

在所有数据库中总计命中：9,681条

1.High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH₂) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5

作者：Richard E. Weaver^a ; Juan C. Mobarec^c ; Mark J. Wigglesworth^b ; ¹ ; Christopher A. Reynolds^c ; Dan Donnelly^a ; ^{d.donnelly@leeds.ac.uk}

关键词：Parathyroid hormone ; PTH ; GPCR ; Agonist ; Receptor ; TIP39

刊名：Biochemical Pharmacology

出版年：2017

2.Synthesis of novel steroidal agonists, partial agonists, and antagonists for the glucocorticoid receptor

作者：Zhuang Jin^a ; Hua Lin^a ; Sathish Srinivasan^b ; Jerome C. Nwachukwu^b ; Nelson Bruno^b ; Patrick R. Griffin^a ; Kendall W. Nettles^b ; ; Theodore M. Kamenecka^a ; ^{kameneck@scripps.edu}

关键词：AF-1 ; activation function-1 ; AF-2 ; activation function-2 ; AP-1 ; activator protein 1 ; dppp ; 1 ; 3-bis(diphenylphosphino)propane ; DEX ; dexamethasone ; DIEA ; N ; N-diisopropylethylamine ; FKBP5 ; FK506-binding protein 5 ; GR ; glucocorticoid receptor ; GRE ; glucocorticoid-response element ; HATU ; 1-[bis(dimethylamino)methylene]-1H-12 ; 3-triazolo[4 ; 5-b]pyridinium 3-oxid hexafluorophosphate ; IL-6 ; Interleukin-6 ; LBD ; ligand-binding domain ; LPS ; lipopolysaccharide ; MMTV ; mouse mammary tumor virus ; NF-κB ; nuclear

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

3.Polar aromatic periphery increases agonist potency of spirocyclic free fatty acid receptor (GPR40) agonists inspired by LY2881835

作者：Mikhail Krasavin^a ; ^{m.krasavin@spbu.ru} ; Alexey Lukin^b ; Daria Bagnyukova^b ; Nikolay Zhurilo^b ; Aleksei Golovanov^b ; Sergey Zozulya^c ; ^d ; Ihor Zahanich^c ; Daniel Moore^e ; Irina G. Tikhonova^e

关键词：Drug discovery ; FFA1 agonists ; Antidiabetic agents ; Spirocyclic motifs ; Hydrophobic interactions ; π&minus ; π stacking

刊名：European Journal of Medicinal Chemistry

出版年：2017

4.Pharmacological studies on the NOP and opioid receptor agonist PWT2-[Dmt¹]N/OFQ(1-13)

作者：Maria Camilla Cerlesi^a ; Huiping Ding^b ; Mark F. Bird^c ; Norikazu Kiguchi^b ; Federica Ferrari^a ; Davide Malfacini^a ; Anna Rizzi^a ; Chiara Ruzza^a ; David G. Lambert^c ; Mei-Chuan Ko^b ; Girolamo Calo^a ; ; Remo Guerrini^d

关键词：PWT2-[Dmt1]N/OFQ(1&ndash ; 13) ; NOP and opioid receptors ; Receptor binding ; Stimulation of [35S]GTPγS binding ; Calcium mobilization ; Monkey spinal analgesia

刊名：European Journal of Pharmacology

出版年：2017

5.Characterization of P2X4 receptor agonists and antagonists by calcium influx and radioligand binding studies

作者：Aliaa Abdelrahman^a ; Vigneshwaran Namasivayam^a ; ^c ; Sonja Hinz^a ; Anke C. Schiedel^a ; Meryem Kö ; se^a ; Maggi Burton^b ; Ali El-Tayeb^a ; ¹ ; Michel Gillard^b ; Jü ; rgen Bajorath^c ; Marc de Ryck^b ; Christa E. Mü ; ller^a ; ^{christa.mueller@uni-bonn.de}

关键词：Ap3A ; diadenosine triphosphate ; Ap4A ; diadenosine tetraphosphate ; Ap5A ; diadenosine pentaphosphate ; AR-C67085MX ; 2-propylthio-β ; γ-dichloromethylene-ATP ; PSB0412 ; 2-propargylthio-β ; γ-dichloromethylene-ATP ; 5-BDBD ; 5-(3-bromophenyl)-1 ; 3-dihydro-2H-benzofuro[3 ; 2-e]-1 ; 4-diazepin-2-one ; BzATP ; 2&prime ; (3&prime ; )-O-(4-benzoylbenzoyl)adenosine 5&prime ; -triphosphate ; CHO-K1 cells ; Chinese hamster ovary cells ; HBSS ; Hank&rsquo ; s balanced salt solution ; HEPES ; 4-(2-hydroxyethyl)-1-piperazine ethanesulfoni

刊名：Biochemical Pharmacology

出版年：2017

6.A benzo[b]thiophene-based selective type 4 S1P receptor agonist

作者：Wooyoung Hur^a ; ¹ ; Hugh Rosen^b ; Nathanael S. Gray^a ; ^{Nathanael_Gray@dfci.harvard.edu}

关键词：Sphingosine-1-phosphate ; S1P receptor ; S1PR4 ; S1P4 ; Selective agonist

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

7.Molecular dynamics simulation of the human estrogen receptor alpha: contribution to the pharmacophore of the agonists

作者：Dessislava Jereva^a ; ^{dessislava.jereva@biomed.bas.bg} ; Filip Fratev^a ; ^b ; ^{fratev@biomed.bas.bg} ; Ivanka Tsakovska^a ; ^{itsakovska@biomed.bas.bg} ; Petko Alov^a ; ^{petko.alov@biophys.bas.bg} ; Tania Pencheva^a ; ^{tania.pencheva@biomed.bas.bg} ; Ilza Pajeva^a ; ^{pajeva@biomed.bas.bg}

关键词：Human estrogen receptor alpha ; Agonist ; Pharmacophore ; Molecular dynamics simulation

刊名：Mathematics and Computers in Simulation

出版年：2017

8.Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists

作者：Sheng-Ren Chen^a ; ^c ; Yi-Yu Ke^a ; ¹ ; Teng-Kuang Yeh^a ; ¹ ; Shu-Yu Lin^a ; Li-Chin Ou^a ; Shu-Chun Chen^a ; Wan-Ting Chang^a ; Hsiao-Fu Chang^a ; Zih-Huei Wu^a ; Chih-Chien Hsieh^a ; Ping-Yee Law^b ; Horace H. Loh^b ; Chuan Shih^a ; Yiu-Kay Lai^c ; ^{yklai@life.nthu.edu.tw} ; Shiu-Hwa Yeh^a ; ^d ; ^{bau9763@bp.nhri.org.tw} ; Shau-Hua Ueng^a ; ^{shueng@nhri.org.tw}

关键词：μ-opioid receptor agonist ; κ-opioid receptor agonist ; Structure-activity relationship ; Blood-brain barrier ; Penetration ; Anti-nociceptive effects ; Tail-flick test

刊名：European Journal of Medicinal Chemistry

出版年：2017

9.Generation of a novel artificial TrkB agonist, BM17d99, using T7 phage-displayed random peptide libraries

作者：Toshiyuki Ohnishi¹ ; Kotaro Sakamoto ; ¹ ; ^{koutarou.sakamoto@takeda.com} ; Asano Asami-Odaka ; Kimie Nakamura ; Ayako Shimizu ; Takashi Ito ; Taiji Asami ; Tetsuya Ohtaki ; Hiroshi Inooka

关键词：Peptide ; Agonist ; TrkB ; BDNF ; Phage display

刊名：Biochemical and Biophysical Research Communications

出版年：2017

10.Role of End Binding Protein-1 in endothelial permeability response to barrier-disruptive and barrier-enhancing agonists

作者：Xinyong Tian ; Tomomi Ohmura ; Alok S. Shah ; Sophia Son ; Yufeng Tian ; Anna A. Birukova ; ^{abirukov@medicine.bsd.uchicago.edu}

关键词：EB1 ; End-Binding Protein-1 ; EC ; endothelial cells ; GEF ; guanine nucleotide exchange factor ; HPAEC ; human pulmonary artery endothelial cells ; MLC ; myosin light chain ; MT ; microtubules ; MYPT1 ; myosin light chain phosphatase ; ns-RNA ; non-specific RNA ; TER ; transendothelial electrical resistance ; XPerT ; express permeability testing assay

刊名：Cellular Signalling

出版年：2017

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