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Elsevier电子期刊(76)

在“Elsevier电子期刊”中，命中：76条，耗时：0.0109873 秒

在所有数据库中总计命中：115条

1.Identification of novel microsomal prostaglandin E₂ synthase-1 (mPGES-1) lead inhibitors from Fragment Virtual Screening

作者：Gianluigi Lauro^a ; Michele Manfra^b ; Silvana Pedatella^e ; Katrin Fischer^d ; Vincenza Cantone^a ; ^d ; Stefania Terracciano^a ; Alessia Bertamino^a ; Carmine Ostacolo^c ; Isabel Gomez-Monterrey^c ; Mauro De Nisco^b ; Raffaele Riccio^a ; Ettore Novellino^c ; Oliver Werz^d ; Pietro Campiglia^a ; ^{pcampiglia@unisa.it} ; Giuseppe Bifulco^a ; ^{bifulco@unisa.it}

关键词：Molecular docking ; Cancer ; Inflammation ; mPGES-1 inhibitors ; Virtual screening

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.2,3-Dihydrobenzofuran privileged structures as new bioinspired lead compounds for the design of mPGES-1 inhibitors

作者：Simone Di Micco^a ; Carmela Spatafora^b ; Nunzio Cardullo^b ; Raffaele Riccio^a ; Katrin Fischer^c ; Carlo Pergola^c ; Andreas Koeberle^c ; Oliver Werz^c ; Malik Chalal^d ; Dominique Vervandier-Fasseur^d ; Corrado Tringali^b ; Giuseppe Bifulco^a ; ^{bifulco@unisa.it" class="auth_mail" title="E-mail the corresponding author}

关键词：GSH ; glutathione ; MAPEG ; membrane-associated proteins in eicosanoid and glutathione metabolism ; MGST-1 ; microsomal glutathione transferase 1 ; mPGES-1 ; microsomal prostaglandin E2 synthase-1 ; COX ; cyclooxygenase ; PG ; prostaglandin

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

3.Insights into the structure activity relationship of mPGES-1 inhibitors: Hints for better inhibitor design

作者：Ashish Gupta ; Polamarasetty Aparoy ; ^{aparoy@cuhimachal.ac.in" class="auth_mail" title="E-mail the corresponding author} ; ^{aparoy@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：mPGES-1 ; Inflammation ; Arthritis ; Osteoarthritis ; Molecular docking ; Structure-activity relationship

刊名：International Journal of Biological Macromolecules

出版年：2016

4.Inhibition of GSK-3 reduces prostaglandin E₂ production by decreasing the expression levels of COX-2 and mPGES-1 in monocyte/macrophage lineage cells

作者：Toshihiro Noma^a ; ^b ; Fumi Takahashi-Yanaga^a ; ^c ; ^{yanaga@clipharm.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Masaki Arioka^a ; Yoshihide Mori^b ; Toshiyuki Sasaguri^a

关键词：GSK-3 ; PGE2 ; COX-2 ; mPGES-1 ; Anti-inflammatory drug

刊名：Biochemical Pharmacology

出版年：2016

5.Discovery of 2-((2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino[2′,3′:3,4]benzo[1,2-d]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E₂ synthase-1 (mPGES-1) inhibitor

作者：Nagarajan Muthukaman^a ; Sanjay Deshmukh^a ; Neelam Sarode^a ; Shital Tondlekar^a ; Macchindra Tambe^a ; Dnyandeo Pisal^a ; Mahamadhanif Shaikh^a ; Vidya G. Kattige^b ; Srinivasa Honnegowda^b ; Vikas Karande^b ; Abhay Kulkarni^b ; Satyawan B. Jadhav^c ; Mahamad Yunnus A. Mahat^c ; Girish S. Gudi^c ; Neelima Khairatkar-Joshi^b ; Laxmikant A. Gharat^a ; ^{Laxmikant.gharat@glenmarkpharma.com}

关键词：Rheumatoid arthritis ; Benzimidazole ; mPGES-1 inhibitor ; PGE2 ; CSF concentration ; Scaffold hopping

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

6.Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors

作者：Steven L. Kuklish^a ; ^{Kuklish_Steven@lilly.com" class="auth_mail" title="E-mail the corresponding author} ; Stephen Antonysamy^b ; Shobha N. Bhattachar^a ; Srinivasan Chandrasekhar^a ; ^&dagger ; ; Matthew J. Fisher^a ; Adrian J. Fretland^a ; ^&Dagger ; ; Karen Gooding^a ; ^&dagger ; ; Anita Harvey^a ; ^&dagger ; ; Norman E. Hughes^a ; John G. Luz^b ; Peter R. Manninen^a ; James E. McGee^a ; Antonio Navarro^a ; Bryan H. Norman^a ; Katherine M. Partridge^a ; Steven J. Quimby^a ; Matthew A. Schiffler^a ; Ashley V. Sloan^a ; Alan M. Warshawsky^a ; Jeremy S. York^a ; Xiao-Peng Yu^a

关键词：mPGES-1 ; Prostaglandin pathway ; Dog bioavailability ; Biomarker

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

7.Identification of novel membrane-associated prostaglandin E synthase-1 (mPGES-1) inhibitors with anti-influenza activities in vitro

作者：Ji Hoon Park^a ; Eun Beul Park^b ; Jae Yeol Lee^b ; Ji-Young Min^a ; ^{jiyoung.min@ip-korea.org" class="auth_mail" title="E-mail the corresponding author}

关键词：Influenza A virus ; Antiviral ; Immunomodulator ; mPGES-1 inhibitor

刊名：Biochemical and Biophysical Research Communications

出版年：2016

8.H₂S dependent and independent anti-inflammatory activity of zofenoprilat in cells of the vascular wall

作者：Martina Monti¹ ; Erika Terzuoli¹ ; Marina Ziche ; Lucia Morbidelli ; PhD ; ^{lucia.morbidelli@unisi.it" class="auth_mail" title="E-mail the corresponding author}

关键词：ACEI ; Angiotensin-converting enzyme inhibitors ; CBS ; cystathionine β-synthase ; COX-2 ; cyclooxygenase-2 ; CSE ; cystathionine gamma-lyase ; eNOS ; endothelial NO synthase ; H2S ; hydrogen sulfide ; HUASM ; human umbilical artery smooth muscle cells ; HUVEC ; human umbilical vein endothelial cells ; IL-1β ; interlukin-1beta ; mPGES-1 ; microsomal prostaglandin E2synthase ; NHDF ; normal human dermal fibroblasts ; NO ; nitric oxide ; PAG ; propargylglycine ; PGE-2 ; Prostaglandin E2 ; PTGIS ; Prostaglandin I2 (prostacycli

刊名：Pharmacological Research

出版年：2016

9.Cytotoxic and pro-oxidative effects of Imperata cylindrica aerial part ethyl acetate extract in colorectal cancer in vitro

作者：Amy Ho Yan Kwok ; Yan Wang ; Wing Shing Ho ; ^{ws203ho@cuhk.edu.hk" class="auth_mail" title="E-mail the corresponding author}

关键词：Imperata cylindrica ; Colorectal cancer ; Prostanoids ; Cytotoxicity ; Oxidative stress

刊名：Phytomedicine

出版年：2016

10.Synthesis and pharmacological characterization of benzenesulfonamides as dual species inhibitors of human and murine mPGES-1

作者：Thomas Hanke ; Florian R枚rsch ; Theresa M. Thieme ; Nerea Ferreiros ; Gisbert Schneider ; Gerd Geisslinger ; Ewgenij Proschak ; Sabine Gr枚sch ; Manfred Schubert-Zsilavecz

关键词：Human mPGES-1 ; Murine mPGES-1 ; Sulfonamides ; SAR ; Inflammation ; Inhibitors

刊名：Bioorganic and Medicinal Chemistry

出版年：15 December, 2013

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