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在“Elsevier电子期刊”中，命中：4,281条，耗时：0.1289395 秒

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1.Quality by design (QbD) approach of pharmacogenomics in drug designing and formulation development for optimization of drug delivery systems

作者：Sumeet Gupta ; ^{sumeetgupta25@gmail.com} ; Vikas Jhawat

关键词：Pharmacogenomics ; Genetic polymorphism ; Genetic markers ; Drug development ; Drug designing ; Drug targets ; Bioinformatics ; Dosage form evaluation and quality by design

刊名：Journal of Controlled Release

出版年：2017

2.Assessment of extracellular field potential and Ca^{2 +} transient signals for early QT/pro-arrhythmia detection using human induced pluripotent stem cell-derived cardiomyocytes

作者：Najah Abi-Gerges^a ; ¹ ; ^{najah.abigeorges@hotmail.com} ; Amy Pointon^a ; Karen L. Oldman^b ; Martin R. Brown^b ; Mark A. Pilling^b ; Clare E. Sefton^b ; Helen Garside^c ; Christopher E. Pollard^a

关键词：Human stem cell-derived cardiomyocytes ; Extracellular field potential ; Ca2 ; + transient ; QT prolongation ; Pro-arrhythmia ; Cardiac safety ; Drug discovery and development

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2017

3.Using X-Ray Crystallography to Simplify and Accelerate Biologics Drug Development

作者：Mark L. Brader¹ ; ^{mbra988@aucklanduni.ac.nz} ; Edward N. Baker¹ ; Michael F. Dunn² ; Thomas M. Laue³ ; John F. Carpenter⁴

关键词：biopharmaceuticals characterization ; biotechnology ; crystal structure ; crystallization ; crystallography ; crystals ; protein formulation ; protein structure

刊名：Journal of Pharmaceutical Sciences

出版年：2017

4.Development of three-dimensional collagen scaffolds with controlled architecture for cell migration studies using breast cancer cell lines

作者：Jonathan J. Campbell^a ; ¹ ; ² ; Anke Husmann^a ; ² ; ^{ah492@cam.ac.uk} ; Robert D. Hume^b ; ² ; Christine J. Watson^b ; Ruth E. Cameron^a

关键词：Breast cancer ; Three dimensional migration ; Collagen 1 ; Ice-templating technique ; Scaffold architecture ; Invasion

刊名：Biomaterials

出版年：2017

5.Development of therapeutic antibodies to G protein-coupled receptors and ion channels: Opportunities, challenges and their therapeutic potential in respiratory diseases

作者：Julie A. Douthwaite^a ; Donna K. Finch^b ; Tomas Mustelin^c ; Trevor C.I. Wilkinson^a ; ^{wilkinsont@medimmune.com}

关键词：ASM ; airway smooth muscle ; CFTR ; cystic fibrosis transmembrane conductance regulator ; COPD ; chronic obstructive pulmonary disease ; FPR ; formyl peptide receptor ; GPCR ; G protein-coupled receptor ; TRP ; transient receptor potential

刊名：Pharmacology & Therapeutics

出版年：2017

6.Imaging in Central Nervous System Drug Discovery

作者：Roger N. Gunn ; PhD^* ; ^&dagger ; ; ^&Dagger ; ; ^{roger.gunn@imanova.co.uk} ; Eugenii A. Rabiner ; FCPsych (SA)^* ; ^§ ;

刊名：Seminars in Nuclear Medicine

出版年：2017

7.Virtual screening and experimental validation identify novel modulators of nuclear receptor RXRα from Drugbank database

作者：Dan Xu¹ ; ^a ; Lijun Cai¹ ; ^a ; Shangjie Guo^a ; Lei Xie^a ; Meimei Yin^a ; Ziwen Chen^a ; Hu Zhou^a ; Ying Su^a ; ^b ; Zhiping Zeng^a ; ^{zengzhiping@xmu.edu.cn} ; Xiaokun Zhang^a ; ^b ; ^{xkzhang@xmu.edu.cn}

关键词：RXRα ; Old drug ; Agonist ; Antagonist ; Virtual screening

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

8.Drug transporters: Starring roles in new drug discovery and development

作者：Yuichi Sugiyama

刊名：Drug Metabolism and Pharmacokinetics

出版年：2017

9.Recent advances on the encoding and selection methods of DNA-encoded chemical library

作者：Bingbing Shi^a ; ^b ; Yu Zhou^a ; ^b ; Yiran Huang^b ; Jianfu Zhang^b ; Xiaoyu Li^b ; ^{xiaoyuli@hku.hk}

关键词：DNA-encoded library ; Drug discovery ; High throughput screening ; Combinatorial chemistry ; Dynamic combinatorial library

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

10.Thiol metabolites, unique but not surprising in drug discovery and development

作者：Peter L. Wang

刊名：Drug Metabolism and Pharmacokinetics

出版年：2017

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