Karst-foundation stability constitutes a major engineering geological problem for the aerodrome construction in Yunnan-Guizhou Plateau. The karst-distribution pattern for the foundation of a planned airport there is studied by geological surveying, mapping, geophysical explorations and drilling. The stability of the karst-foundation is evaluated by analyzing the location, scope, depth, morphological characteristics and development factors of the karst, to provide a geological preparation for the engineering construction.