This paper reviews the factors impacting on the long-term performance of Fe0-PRBs in treating chlorinated solvents, including groundwater chemistry, mineral precipitates formed on iron surface, microbes within Fe0-PRBs and other coexistent organic pollutants. It is mineral precipitates accumulating within Fe0-PRBs that become the predominant factor to decrease barriers’ reactivity over time. Moreover, future research on multimedia permeable reactive barriers and sequential ones based on Fe0-PRBs have been recommended.