///According to the study on physical and chemical conditions and sulfur and lead isotope of Keketale Pb-Zn deposit in Xinjiang, it can be concluded that the deposit formation temperature is 300℃; logfS2 is-32.75~-33.91, logfS2 is -6.75~-10.00; pH is 5.3~7.0. The ratio of 206Pb/204Pb, 207Pb/204Pb and 208Pb/204Pb in ore and gangue are 18.001~18.200, 15.480~ 15.705 and 37.605~38.861 respectively. The δ34S of sulfide is in the range of-15.8‰~+5.1‰, δ34S of pyrite is in the range of -14.3‰~+5.1‰, δ34S of galena is in the range of -15.8‰~-1.0‰, δ34S of magnetic pyrite is in the range of -14.6‰~-1.4‰, δ34S of zinc blende is in the range of -14.5‰~-11.3‰. Sulfur isotope indicates that sulfur originates from magma, while lead isotope indicates that lead comes from multiple sources.