Based on the complicated geological conditions in Cretaceous strata scientific drilling in Jiao-Lai basin, the pa-per introduces the construction about the borehole structure, BHA, flushing fluid selection and drilling technical parame-ters.According to the difficult problems of hydration dispersion in mudstone strata, oversized diameter caused by borehole collapse and bit balling, the solutions for advanced open borehole drilling and the selection of low solid inhibited flushing fluid and drill bit are mainly discussed.