In this paper, geological, ore-forming and chemical characteristics of the intercrystalline brine minerogenetic belt of K-rich nitrate in the southern margin of East Tianshan are summarized, geological and climatic factors, sources of mineral-forming elements and resource status are analyzed, and some prospecting suggestions concerning the potential resources are put forward. The K-rich nitrate deposits, a special kind of ore deposits, were formed under a particular structural condition, which seems to be an important factor for salt source and minerogenetic process. The intercrystalline brines, interstratal brines and fissure brines constitute considerable potential resources.