By supporting of ARCGIS software the changes of ground ice content and active layer thickness of Qinghai-Tibetan Plateau permafrost region are calculated by using ground ice model and Stefan equation under different climate change scenarios. The results show that: the distribution of permafrost will not have a significant change in the next few decades but large-scale changes will take place at the end of this century. The main permafrost degradation types are the melting of ground ice and converted the low-temperature to high-temperature permafrost. The large-scale changes will accompany with the thermal hazards such as thermokarst and thermal slump.