In order to know the geochemical characteristics of Shuidong lead-zinc deposit in Nayong, it sampling the lead-zinc ore of Dengying Formation in Ximigou, Fenshanjiao area in Shuidong, it does under microscope analyses and the geochemical study of major, rare element, REE and sulfur isotope of whole rocks. The study of rare element shows that Ni, Mo, As, Sb and other mineral element concentration are obvious, the depletion of Sr, Ba, V and other element are strong. It’s thought the thermal water in Early Cambrian did leaching and reconstruction to the lead-zinc mineral source layer. The study of REE shows the Quantitative REE Modeling is acclivitous to right, both δEu and δCe is negative anomalies, is the same as the clastic sediment and rare earth association in seawater, means that the mineral material must has the terrigenous material.