Through employing the method of geostatistics, making an analysis of the copper grade of the 5th ore body, and conducting curve fitting of the theoretical variable function, the authors established a mathematical model for the Yangla ore deposit. On such a basis, the reserves were calculated by using the Kriging and the inverse square distance methods. In combination with the statistics of reserves calculated by the traditional block method, the three methods were compared with each other. The impact factors of the three methods and the fundamental causes for their errors were discussed. It is found that the Kriging method for reserves calculation is the most advanced and applicable means. This paper has also analyzed the copper grade-tonnage curves for the ore body, and the result can provide a reliable theoretical basis for reasonable determination of economic grade and tonnage in the mine.