In order to assess the oil and gas resource potential of Pre-Cenozoic in the South China Sea (SCS), macro-distribution of Pre-Cenozoic residual basins is studied by using integrated geophysical methods. The results show that Pre-Cenozoic residual basins of the South China Sea have a good potential for oil and gas resources, such as Dongsha uplift, Chaoshan Depression, Southwest Taiwan Basin of northeastern South China Sea, Peikang uplift of western Taiwan, and Liyue Basin (Reed Tablemount) of southern South China Sea.