A great number of granites that widely exposed in Altay metallogenic belt, Xinjiang, are closely related to mineralization. This paper studies on the Keketale biotite granite body outcropped in Keketale lead-zinc mineral district. The granite body yields a LA-ICP-MS zircon U-Pb age of (401.8 ± 1.5) Ma, which means that the Keketale granite body is the product of an important magmatism-tectonism happened in the period about 400 Ma in Altay metallogenic belt. The biotite granite body intruded into the volcanic strata of Lower Devonian Kangbutiebao group, and there are obvious alterations of wall-rocks shown in the contact zone between the granite body and wall rocks.