By combining hydrocarbon source rocks and seismic response characteristics,starting from measuring organic carbon content,using logging prediction method of TOC to build TOC curve of the virtual well,as dependent variables,and selecting seismic attributes as independent variables,this paper establishes the best fitting equation and extracts seismic attributes from 3D seismic data to calculate the 3D TOC data body.The method is applied to the rich-in hydrocarbon-generating Huizhou Depression of Pearl River Mouth Basin in China,and calculates the 3D TOC data body of the overall Wenchang Group and Enping Group.