Determination of lower limit of geochemical anomaly is very important to delimitation of favorable mineral exploration targets and guiding the survey. With survey of 5 elements of As, Cr, Ni, Sn and Th in stream sediments in the Xitieshan area, Qinghai Province as example, this paper applied scalping method, EDA method and iterative method to data processing respectively to determine anomalous lower limit. By comparison, scalping method and EDA method gave a bit higher lower limit, incapable of effectively delimiting favorable mineralization targets, while iterative method-determined lower limit did not miss any significant weak anomalies. So, iterative method is reasonably applicable to this area.