The deep beds of Changling fault depression is characterized by rich natural gas which can reach from 1.14×1012 m3 to 1. 71×1012 m3 (the average value is 1.42×1012 m3) according to the results of petroleum system simulation. The hydrocarbon gases and CO2 are distributed in different areas: the east part of the depression is rich in hydrocarbon gases ; the west part is rich in CO2; the middle part is rich in the both kinds of gases. The distribution of hydrocarbon gases are controlled by source rocks, while the CO2 is closely related to the volcanic rocks and major basement faults.The comprehensive evaluations show five favorable regions, among which one is belong to type I , three belong to type II, one belong to type III. The type I and type II are the favorable regions to explore for the next step.