Nyainqentanglha Early Eocene intermediate-basic intrusive rocks consist of amphibole gabbro and monzodiorite. The zircon LA-MC-ICPMS U-Pb dating for the amphibole gabbro defines a crystallizationage of (49.92±0.24) Ma. The intermediate-basic intrusive rocks are high-K calc-alkaline to shoshonite series based on the SiO2-K2O diagram. Analysis indicates that they come from an enriched mantle metasomatized by ancient continental crust. REE simulation suggests that the forming processes for the intermediate-basic intrusive rocks were controlled by low tomoderate partial melting of the enriched mantle. The dynamic background for the intermediate-basic intrusive rocks are likely linked to breakoff of Neo-Tethyan slab followed by upwelling of asthenospheric materials from the slab window.