Study on the Adsorption and Sustained-Release Performance of Ca-Montmorillonite for Carmofur

• 责任者：Wang Guifang (College of Chemical and Environmental Engineering ; SDUST ; Qingdao 266510 ; China) ; Qiu Jun
• 刊名：Journal of Mineralogy and Petrology
• 出版年：2010
• 卷期：30(1)
• 关键词：蒙脱石 ; montmorillonite ; 药用矿物 ; medicinal minerals
• 页码：p.6-11
• 图表：5 illus., 3 tables, 17 refs.
• 分类号：0700
• issnNo：ISSN1001-6872
• isbnNo：CN51-1143/TD

In order to investigate the adsorptions properties of two types of montmorillonite for carmofur(HCFU)and releasing behaviour, and discuss the feasibility of montmorillonite used as the sustained-releasing drug carrier, the adsorption of montmorillonite for HCFU and the in vitro releasing experiments of HCFU were conducted by stability temperature oscillated method and dialysis method respectively.Two mathematical models of drug release were used to fit the releasing of HCFU from HCFU/MMT complexes into various initial pH aqueous solutions. The results indicated that the releasing process of HCFU from HCFU/MMT complexes into various aqueous solutions was changed with pH value of the solutions, and the in vitro releasing behaviour of HCFU from the HCFU/MMT complexes involved physical diffusion, ions exchange and drug dissolution