Actual subsurface media is characterized by extensive anisotropy, which leads to relatively low imaging accuracy by using isotropic pre-stack depth migration method. Therefore, a workflow of VTI anisotropic pre-stack depth migration was proposed. On the basis of isotropic pre-stack depth, VTI anisotropic parameters are obtained and VTI anisotropic pre-stack depth migration is carried out. The workflow was applied to the data processing in JZ block. The comparison between VTI anisotropic and isotropic pre-stack migration result indicate that VTI anisotropic pre-stack depth migration can improve the imaging accuracy of complex faulted area.