The 2010 Yushu earthquake registered a magnitude of MS 7. 1. This paper discusses the origin and background of the earthquake and gives some advices about post-disaster reconstruction. Just because the eastward movement of Kunlun block leading to the sinistral slip of Yushu-Xianshuihe Fault, then caused the 2010 Yushu earthquake. Until now, the eastward movement of Kunlun block had caused three earthquakes with the magnitude of MS 7 to MS 8, massive accumulated energy had been released. So, the emphasis should be focused on the southeastward moving Qiangtang-Litang block and a strict surveillance must be kept on it. The authors proposed that the following areas could be struck by earthquakes: Yuxi, Tonghai and Shiping areas in the south of Kunming; Dali area; Yanyuan and Yantang areas of western Sichuan Province; Ya’an, Luding and Kangding areas, which are the cross section of Yushu-Xianshuihe Fault and Longmen Mountain Fault. High attention with dynamic monitoring should be paid to these areas.