On the basis of the comprehensive analyses of the depositional sequence of the Cretaceous-Neogene outcrop sections, and the seismic sequence and drill-hole information in Tarim Basin, the authors hold that the Cretaceous-Neogene strata can be divided into 32 depositional sequences in the southwestern depression and 27 depositional sequences in the northwestern depression. This proves the characteristics of the basin-orogen coupling evolution between the depositional filling of southwestern depression and northwestern depression and lifting-fall process of Tianshan and Kunlunshan orogens.