上海市2002—2006年胰腺癌人群生存状况研究
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摘要
目的分析上海2002—2006年发病的胰腺癌患者生存情况。方法利用上海市肿瘤登记处收集的2002—2006年胰腺癌登记和生存随访报告资料,采用寿命表法和EdererⅡ法计算胰腺癌患者的观察生存率(OS)和相对生存率(RS),分析影响胰腺癌患者生存率的因素。结果 2002—2006年上海市胰腺癌患者5年OS为6.63%,RS为10.11%。不同年龄段胰腺癌患者的5年OS不同,随着年龄增大,生存率逐渐降低。诊断时期为Ⅰ期、Ⅱ期的胰腺癌患者生存率高于Ⅲ期、Ⅳ期。肿瘤位于胰体的患者生存率高于其他部位。不同性别、市郊间患者生存率无明显差别。30年间,上海市区男女胰腺癌生存率均有所上升。结论上海市胰腺癌生存率逐步提高,年龄、肿瘤分期、亚部位等因素对胰腺癌生存率有影响。
Objective To analyze survival situation of pancreatic cancer patients in Shanghai from 2002 to 2006.Methods Based on the cancer registration data collected by Shanghai Cancer Registry for the pancreatic cancer patients in Shanghai from 2002 to 2006 as well as the reports of the follow-up visits thereof,the Life Table and the Ederer Ⅱ method were used to calculate the observed survival(OS) and the relative survival(RS) thereof and to analyze the factors influencing survival rates thereof.Results The 5-year OS and RS of pancreatic cancer patients in Shanghai from 2002 to 2006 were 6.63% and 10.11%,respectively.The 5-year OS varied with each age group of pancreatic cancer patients.With the age increase of pancreatic cancer patients,the survival rate thereof gradually decreased.The survival rates of pancreatic cancer patients diagnosed to be at Phase Ⅰ and Phase Ⅱ were higher than those thereof diagnosed to be at Phase Ⅲ and Phase Ⅳ.The survival rate of the patients for whom pancreatic cancer was sited at body of pancreas was higher than that of the patients for whom pancreatic cancer was sited elsewhere.For the survival rate thereof,there were no significant differences between different genders,or between the urban and the suburbs/outskirts.In the past 30 years,the survival rates for both male and female patients with pancreatic cancer in the urban area of Shanghai increased to a certain extent.Conclusion The survival rate of pancreatic cancer patients in Shanghai increases on a yearly basis.Age(of patients),phasing(of pancreatic cancer),subsite(location)(of pancreatic cancer),etc.will all influence the survival rates of pancreatic cancer patients.
Objective To analyze survival situation of pancreatic cancer patients in Shanghai from 2002 to 2006.Methods Based on the cancer registration data collected by Shanghai Cancer Registry for the pancreatic cancer patients in Shanghai from 2002 to 2006 as well as the reports of the follow-up visits thereof,the Life Table and the Ederer Ⅱ method were used to calculate the observed survival(OS) and the relative survival(RS) thereof and to analyze the factors influencing survival rates thereof.Results The 5-year OS and RS of pancreatic cancer patients in Shanghai from 2002 to 2006 were 6.63% and 10.11%,respectively.The 5-year OS varied with each age group of pancreatic cancer patients.With the age increase of pancreatic cancer patients,the survival rate thereof gradually decreased.The survival rates of pancreatic cancer patients diagnosed to be at Phase Ⅰ and Phase Ⅱ were higher than those thereof diagnosed to be at Phase Ⅲ and Phase Ⅳ.The survival rate of the patients for whom pancreatic cancer was sited at body of pancreas was higher than that of the patients for whom pancreatic cancer was sited elsewhere.For the survival rate thereof,there were no significant differences between different genders,or between the urban and the suburbs/outskirts.In the past 30 years,the survival rates for both male and female patients with pancreatic cancer in the urban area of Shanghai increased to a certain extent.Conclusion The survival rate of pancreatic cancer patients in Shanghai increases on a yearly basis.Age(of patients),phasing(of pancreatic cancer),subsite(location)(of pancreatic cancer),etc.will all influence the survival rates of pancreatic cancer patients.
引文
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[15]韩序,赵婧,方圆,等.年龄对胰腺神经内分泌肿瘤患者术后生存的影响[J].中华消化外科杂志,2012,11(4):346-350.
[16]TAS F,SEN F.KESKIN S,et al.Prognostic factors in metastatic pancreatic cancer:Older patients are associated with reduced overall survival[J].Mol Clin Oncol,2013,1(4):788-792.
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[18]李文英,张晓峰,曹淑红,等.胰腺癌手术患者115例的预后分析[J].中国老年学杂志,2011,31(15):2867-2869.
[19]陈祺,李东恩,姜建帅,等.195例早期胰腺癌手术方式与生存率的关系[J].中国中西医结合外科杂志,2016,(1):3-5.
[20]LAU M K.DAVILA J A.SHAIB Y H.Incidence and survival of pancreatic head and body and tail cancers:a population-based study in the United States[J].Pancreas,2010,39(4):458-462.
[21]ELOUBEIDI M A,DESMOND R A,WILCOX C M,et al.Prognostic factors for survival in pancreatic cancer;a population-based study[J].Am J Surg,2006,192(3):322-329.
[22]FESINMEYER M D.AUSTIN MA,LI C I,et al.Differences in survival by histologic type of pancreatic cancer[J].Cancer Epidemiol Biomarkers Prev,2005,14(7);1766-1773.
[23]YADAV S.SHARMA P.ZAKALIK D.Comparison of Demographics,Tumor Characteristics,and Survival Between Pancreatic Adenocarcinomas and Pancreatic Neuroendocrine Tumors:A Population-based Study[J].Am J Clin Oncol,2016 Jun 17.[Epub ahead of print]
[24]田明,严俊,胡进静,等.胰腺癌流行现状及危险因素综述[J].中国社会医学杂志,2016,33(2):137-140.
[2]马臣,姜永晓,刘曙正,等.中国胰腺癌发病趋势分析和预测[J].中华流行病学杂志,2013,34(2):160-163.
[3]CHEN W,ZHENG R.BAADE PD.et al.Cancer statistics in China,2015[J].CA Cancer J Clin,2016,66(2):115-132.
[4]CARRATO A,FALCONE A,DUCREUX M,et al.A systematic review of the burden of pancreatic cancer in europe:realworld impact on survival,quality of life and costs[J].J Gastrointest Cancer,2015,46(3):201-211.
[5]BOSMAN F T.CARNEIRO F.HRUBAN R H.et al.WHO classification of tumours of the digestive system[M].Lyon France:IARC 2010:280.
[6]KAPLAN EL,MEIER P.Nonparametric estimation from incomplete observations[J].J Am Stat Soc,1958,53:457-481.
[7]ESTEVE J.BENHAMOU E.RAYMOND L.Statistical Methods in Cancer Research,volume IV:Descriptive Epidemiology[M].Lyon France:IARC Scientific Publications,1994:247-255.
[8]高玉堂,卢伟.上海市区恶性肿瘤发病率、死亡率和生存率(1973-2000)[M].上海:第二军医大学出版社,2007:417-419.
[9]LUKE C,PRICE T.KARAPETIS C,et al.Pancreatic cancer epidemiology and survival in an Australian population[J].Asian Pac J Cancer Prev.2009,10(3):369-374.
[10]CRONIN-FENTON D P.RUNE E.MORTENSEN F V,et al.Pancreatic cancer survival in central and northern Denmark from 1998 through 2009:a population-based cohort study[J].Clin Epidemiol.2011,3(Suppl 1):19-25.
[11]SIRRI E,CASTRO F A.KIESCHKE J,et al.Recent trends in survival of patients with pancreatic cancer in Germany and the United States[J].Pancreas,2016,45(6):908-914.
[12]丁璐璐,陈建国,朱健,等.启东市1972-2011年胰腺癌生存率分析[J].中华胰腺病杂志,2015,15(2):73-77.
[13]邓世敏,李南,梁艳,等.重庆市九龙坡区2008-2013年主要恶性肿瘤生存率分析[J].中华肿瘤防治杂志,2014,21(16):1223-1226.
[14]ARNACHELLUM R P,CARIOU M.NOUSBAUM J B,et al.Pancreatic Adenocarcinoma in the Finistere Area,France,between 2002 and 2011(1002 cases):population characteristics,treatment and survival[J].Pancreas,2016,45(7):953-960.
[15]韩序,赵婧,方圆,等.年龄对胰腺神经内分泌肿瘤患者术后生存的影响[J].中华消化外科杂志,2012,11(4):346-350.
[16]TAS F,SEN F.KESKIN S,et al.Prognostic factors in metastatic pancreatic cancer:Older patients are associated with reduced overall survival[J].Mol Clin Oncol,2013,1(4):788-792.
[17]CHEUNG R.Racial and social economic factors impact on the cause specific survival of pancreatic cancer;a SEER survey[J].Asian Pac J Cancer Prev,2013,14(1):159-163.
[18]李文英,张晓峰,曹淑红,等.胰腺癌手术患者115例的预后分析[J].中国老年学杂志,2011,31(15):2867-2869.
[19]陈祺,李东恩,姜建帅,等.195例早期胰腺癌手术方式与生存率的关系[J].中国中西医结合外科杂志,2016,(1):3-5.
[20]LAU M K.DAVILA J A.SHAIB Y H.Incidence and survival of pancreatic head and body and tail cancers:a population-based study in the United States[J].Pancreas,2010,39(4):458-462.
[21]ELOUBEIDI M A,DESMOND R A,WILCOX C M,et al.Prognostic factors for survival in pancreatic cancer;a population-based study[J].Am J Surg,2006,192(3):322-329.
[22]FESINMEYER M D.AUSTIN MA,LI C I,et al.Differences in survival by histologic type of pancreatic cancer[J].Cancer Epidemiol Biomarkers Prev,2005,14(7);1766-1773.
[23]YADAV S.SHARMA P.ZAKALIK D.Comparison of Demographics,Tumor Characteristics,and Survival Between Pancreatic Adenocarcinomas and Pancreatic Neuroendocrine Tumors:A Population-based Study[J].Am J Clin Oncol,2016 Jun 17.[Epub ahead of print]
[24]田明,严俊,胡进静,等.胰腺癌流行现状及危险因素综述[J].中国社会医学杂志,2016,33(2):137-140.
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