冰冻云南白药膏贴敷疗法对脑出血头痛患者内皮素-1、肿瘤坏死因子-α、白介素-6的影响
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摘要
目的:观察冰冻云南白药膏贴敷疗法对脑出血头痛患者的内皮素-1、肿瘤坏死因子-α、白介素-6的影响。方法:将2015年7月~2016年6月住院的自发性脑出血患者随机分为观察组和对照组,对照组按指南给予常规治疗,观察组在常规治疗基础上加用冰冻处理后的云南白药膏治疗,疗程14d,观察两组患者治疗前后内皮素-1、肿瘤坏死因子-α、白介素-6情况。结果:冰冻云南白药膏贴敷疗法可降低脑出血头痛患者血浆内皮素-1、血清肿瘤坏死因子-α、血清白介素-6水平,治疗前后两两比较差异有统计学意义(P<0.05)。结论:冰冻云南白药膏贴敷疗法可减轻脑出血患者头痛症状,其机制可能与其降低内皮素-1、肿瘤坏死因子-α、白介素-6水平有关。
Objective:To observe the effects of frozen Yunnan Baiyao Ointment on endothelin-1,Tumor necrosis factor-a and interleukin-6 in patients with cerebral hemorrhage headache.Methods:From July 2015 to June 2016,106 patients with spontaneous intracerebral hemorrhage were randomly divided into two groups:the observation group and the control group.The control group was given conventional treatment according to the guideline.After the routine treatment,Yunnan Baiyao paste treatment,treatment 14 d,The levels of endothelin-1,tumor necrosis factor-a and interleukin-6 were observed before and after treatment.Results:Yunnanbaiyao ointment could decrease the level of plasma endothelin-1,serum tumor necrosis factor-a and serum interleukin-6 in patients with cerebral hemorrhage headache.There was significant difference between the two groups(P<0.05).Conclusion:Frozen Yunnanbaiyao ointment can relieve headache symptoms in patients with intracerebral hemorrhage.The mechanism may be related to the decrease of endothelin-1,tumor necrosis factor-α and interleukin-6.
Objective:To observe the effects of frozen Yunnan Baiyao Ointment on endothelin-1,Tumor necrosis factor-a and interleukin-6 in patients with cerebral hemorrhage headache.Methods:From July 2015 to June 2016,106 patients with spontaneous intracerebral hemorrhage were randomly divided into two groups:the observation group and the control group.The control group was given conventional treatment according to the guideline.After the routine treatment,Yunnan Baiyao paste treatment,treatment 14 d,The levels of endothelin-1,tumor necrosis factor-a and interleukin-6 were observed before and after treatment.Results:Yunnanbaiyao ointment could decrease the level of plasma endothelin-1,serum tumor necrosis factor-a and serum interleukin-6 in patients with cerebral hemorrhage headache.There was significant difference between the two groups(P<0.05).Conclusion:Frozen Yunnanbaiyao ointment can relieve headache symptoms in patients with intracerebral hemorrhage.The mechanism may be related to the decrease of endothelin-1,tumor necrosis factor-α and interleukin-6.
引文
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[2]Anderson CS,Heeley E,Huang Y,et al.Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage[J].N EnglJMed,2013,368(25):2355-2365.
[3]全国第四届脑血管病学术会议通过.脑卒中患者临床神经功能缺损程度评分标准[J].中华神经科杂志,1996,29(6):381-383.
[4]陈汉杰,邹社昌,陈文鑫.依达拉奉对高血压脑出血患者炎症细胞因子水平的影响[J].中国实用神经疾病杂志,2014,17(7):38-40.
[5]陆伟恒,苏斌儒,罗成宏,等.依达拉奉对高血压脑出血患者炎症细胞因子水平的影响[J].临床医学工程.2015.22(3):307-308.
[6]石滴坚,程泽沛,曾龙威.醒脑静注射液对高血压脑出血微创碎吸术后患者血细胞因子的影响[J].中国药业,2013,22(13);5-6.
[7]庄严,王丹丹,李欣.等.高血压性脑出血患者血一氧化氮内皮素1和肿瘤坏死因子-α水平的变化[J].中华高血压杂志,2011,19(4):384-386.
[8]张昌盛,阿古拉,朝鲁门,等.蒙医震脑术治疗偏头痛的疗效及对血浆一氧化氮和内皮素的影响[J].中国中医急症,2015,24(1):7-9,12.
[9]张华新,张宝霞,李大军,等.云南白药膏对脑出血后肿瘤坏死因子-α、白介素-1β水平的影响[J].中国中医急症,2015,24(12):2216-2218.
[10]荣英蕊,刘建平,郎晓猛,等.辛伐他汀对急性脑梗死患者血清CRP及IL-6水平影响的临床研究[J].中国社区医师(医学专业),2011,13(12):64-65.
目录