Failure of transplantation tolerance induction by autologous regulatory T cells in the pig-to-non-human primate islet xenotransplantation model
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- 作者：Jun-Seop Shin ; Byoung-Hoon Min ; Jong-Min Kim ; Jung-Sik Kim ; Il Hee Yoon ; Hyun Je Kim ; Yong-Hee Kim ; Jae Yool Jang ; Hee Jung Kang ; Dong-Gyun Lim ; Jongwon Ha ; Sang-Joon Kim and Chung-Gyu Park
- 刊名：Xenotransplantation
- 出版年：2016
- 出版时间：July/August 2016
- 年：2016
- 卷：23
- 期：4
- 页码：300-309
- 全文大小：1484K
- ISSN：1399-3089
文摘
Islet allotransplantation is a promising way to treat some type 1 diabetic (T1D) patients with frequent hypoglycemic unawareness, and islet xenotransplantation is emerging to overcome the problem of donor organ shortage. Our recent study showing reproducible long-term survival of porcine islets in non-human primates (NHPs) allows us to examine whether autologous regulatory T-cell (Treg) infusion at peri-transplantation period would induce transplantation tolerance in xenotransplantation setting.