Identification of subgroups with differential treatment effects for longitudinal and multiresponse variables

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• 作者：Wei-Yin Loh ; Haoda Fu ; Michael Man ; Victoria Champion and Menggang Yu
• 刊名：Statistics in Medicine
• 出版年：2016
• 出版时间：20 November 2016
• 年：2016
• 卷：35
• 期：26
• 页码：4837-4855
• 全文大小：1978K
• ISSN：1097-0258

文摘

We describe and evaluate a regression tree algorithm for finding subgroups with differential treatments effects in randomized trials with multivariate outcomes. The data may contain missing values in the outcomes and covariates, and the treatment variable is not limited to two levels. Simulation results show that the regression tree models have unbiased variable selection and the estimates of subgroup treatment effects are approximately unbiased. A bootstrap calibration technique is proposed for constructing confidence intervals for the treatment effects. The method is illustrated with data from a longitudinal study comparing two diabetes drugs and a mammography screening trial comparing two treatments and a control. Copyright