Effect of Sodium Alginate on the Properties of Thermosensitive Hydrogels

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• 作者：Jie Wu ; Zongmei Wu ; Xuejiao Sun ; Shichao Yuan ; Ruling Zhang ; Qingliang Lu and Yueqin Yu
• 刊名：Journal of the Chinese Chemical Society
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：64
• 期：2
• 页码：231-238
• 全文大小：464K
• ISSN：2192-6549

文摘

Sodium alginate (SA) was combined with poly(N-isopropylacrylamide) (PNIPAAm) to prepare thermosensitive hydrogels through semi-interpenetrating polymer network (semi-IPN) and fully interpenetrating polymer network (full-IPN). The thermosensitive, swelling, mechanical, and thermal properties of pure PNIPAAm, SA/PNIPAAm semi-IPN, and Ca-alginate/PNIPAAm full-IPN hydrogels were investigated. The formation of semi-IPN and full-IPN significantly improved the hydrogels’ swelling capability and mechanical properties without altering their thermosensitivity. 5-Fluorouracil (5-Fu) was selected as a model drug to study the release behaviors of the hydrogels. It was found that in vitro controlled drug release from semi-IPN hydrogels showed an initial release burst, followed by a slower and sustained release, before reaching equilibrium. Full-IPN hydrogels showed slow and sustained release during the whole process. Temperature and pH were found to affect the rate of drug release. Ca-alginate/PNIPAAm full-IPN hydrogels have potential application as drug delivery matrices in controlled drug release.