AuNP-Collagen Matrix with Localized Stiffness for Cardiac-Tissue Engineering: Enhancing the Assembly of Intercalated Discs by β1-Integrin-Mediated Signaling
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- 作者：Yi Li ; Xiaoli Shi ; Lei Tian ; Hongyu Sun ; Yujing Wu ; Xia Li ; Jianjun Li ; Yujie Wei ; Xinxiao Han ; Jiao Zhang ; Xiaowei Jia ; Rui Bai ; Limin Jing ; Peng Ding ; Huiliang Liu and Dong Han
- 刊名：Advanced Materials
- 出版年：2016
- 出版时间：December 14, 2016
- 年：2016
- 卷：28
- 期：46
- 页码：10230-10235
- 全文大小：3719K
- ISSN：1521-4095
文摘
A schematic for the mechanism of accelerating the assembly of intercalated discs (IDs) in cardiac myocytes regulated by gold nanoparticles (AuNPs) is presented. AuNPs with local nanoscale stiffness in the substrate activate β1-integrin signaling, which mediates the activation of integrin-linked kinase (ILK) and its downstream signal kinase by stimulating expression of the transcription factors GATA4 and MEF-2c.