Iodine-Catalyzed Formation of Amide Bond: Efficient Strategy for the Synthesis of Aromatic Primary Amides

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• 作者：Dr. Zengyang Xie ; Dr. Ruijiao Chen ; Dr. Zhongyu Du ; Lingdong Kong ; Zhenquan Li ; Dr. Zhaolou Li ; Prof. Ning Wang and Prof. Jun Liu
• 刊名：Asian Journal of Organic Chemistry
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：6
• 期：2
• 页码：157-160
• 全文大小：483K
• ISSN：2193-5815

文摘

A practical and efficient methodology for the synthesis of aromatic primary amides by reaction of benzylic alcohols and aqueous ammonia in the presence of an I₂/TBHP system in acetonitrile was developed. This oxidative amidation proceeded smoothly at ambient temperature and tolerated a variety of functional groups. A wide range of aromatic primary amides were obtained in moderate to high yields. Preliminary kinetic studies and a possible mechanism of the oxidative amidation reaction were also discussed.