Anti-inflammatory activity of chitosan nanoparticles carrying NF-κB/p65 antisense oligonucleotide in RAW264.7 macropghage stimulated by lipopolysaccharide
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- 作者：Li Maa ; Chuan-an Shena ; shenchuanan@126.com" class="auth_mail" title="E-mail the corresponding author ; Lei Gaob ; Da-wei Lia ; Yu-ru Shanga ; Kai Yina ; Dong-xu Zhaoa ; Wen-feng Chenga ; Dong-qin Quanc
- 关键词：Chitosan nanoparticles ; Sepsis ; Nuclear factor-kappa B ; Anti-sense gene ; Macrophages
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：142
- 期：Complete
- 页码：297-306
- 全文大小：3005 K
文摘
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Nanopartaicles were prepared between NF-κB/p65 antisense gene (NAG) and chitosan.
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NAG chitosan NPs had low toxic effect on RAW264.7 macrophages.
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NAG chitosan NPs were capable to deliver NAG into cytoplasm and nucleus.
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NAG chitosan NPs significantly decreased the activation and protein expression level of NF-κB/p65.
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Release level of inflammatory factors was decreased by NAG chitosan NPs.
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