Role for NF-κB inflammatory signalling pathway in tenofovir disoproxil fumarate (TDF) induced renal damage in rats

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• 作者：Hemalatha Ramamoorthy^a ; Premila Abraham^a ; ^{premilaabraham@cmcvellore.ac.in} ; Bina Isaac^b ; Dhayakani Selvakumar^a
• 关键词：Tenofovir ; Renal damage ; NFκB signalling ; iNOS ; COX-2 ; TNFα
• 刊名：Food and Chemical Toxicology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：99
• 期：Complete
• 页码：103-118
• 全文大小：7394 K
• 卷排序：99

文摘

NFκB plays a role in tenofovir induced renal damage. There is increased mRNA, protein and activity of NFκBp65. NFκB target genes-iNOS, COX-2 and TNFα are upregulated. Melatonin pretreament inhibits NFκB activation. Melatonin prevents TDF induced renal damage.