Extension of market exclusivity and its impact on the accessibility to essential medicines, and drug expense in Thailand: Analysis of the effect of TRIPs-Plus proposal

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• 作者：Chutima Akaleephan ; Suwit Wibulpolprasert ; Rungpetch Sakulbumrungsil ; Paithip Luangruangrong ; Anchalee Jitraknathee ; Achara Aeksaengsri ; Siripa Udomaksorn ; Viroj Tangcharoensathien ; Sripen Tantivess
• 关键词：TRIPs-Plus ; Market exclusivity ; Generic drugs ; Cost saving ; Policy ; Patents as topic ; Intellectual property
• 刊名：Health Policy
• 出版年：2009
• 出版时间：July 2009
• 年：2009
• 卷：91
• 期：2
• 页码：174-182
• 全文大小：478 K

文摘

Background

In Thailand and the US negotiating FTA, the ‘TRIPs-Plus’ is one of the US proposal which would result in an extension of market exclusivity of innovative drugs. In addition, it would foreseeably lead to high and unaffordable medicine prices and inaccessibility to essential medicines.

Objective

To quantify the impact on medicine expense and medicine accessibility.

Methods

Based on 2000 to 2003 Thai Food and Drug Administration (FDA)’s and the Drug & Medical Supply Information Center (DMSIC), costs and accessibility were estimated upon the price and quantity costing between innovative drugs and their generics plus some parameters found from their competitive behaviour. Thereafter, we simulated the 10-year potential additional expense on the 2003 unit price of the patented and monopolized non-patented medicines.

Results

In 2003, the availability of generics helped to save 104.5 % of actual expense and the accessibility would increase by 53.6 % . By extension of market exclusivity, given that there were 60 new items approved annually, the cumulative potential expense was projected to be $US 6.2 million for the first year to $US 5215.8 million in tenth year.

Conclusion

The TRIPs-Plus proposal would result in a significant increase in the medicine expense; and a delay in the increase in drug accessibility via generics. Several options as well as other related mechanisms to help reduce the negative impact are proposed.