H₂S inhibits angiotensin II-induced atrial Kv1.5 upregulation by attenuating Nox4-mediated ROS generation during atrial fibrillation

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• 作者：Guihua Lu^a ; ^b ; Chenggui Xu^a ; ^b ; Kaiyu Tang^a ; Juhong Zhang^a ; Qinglang Li^a ; Longyun Peng^a ; Yesong Wang^a ; Zhibin Huang^a ; ^{hzbin2603@163.com} ; Xiuren Gao^a ; ^{xiurengao03@163.com}
• 关键词：Hydrogen sulfide ; Angiotensin II ; Kv1.5 ; Reactive oxygen species ; Atrial fibrillation
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：534-540
• 全文大小：917 K
• 卷排序：483

文摘

Mechanisms of H2S-related downregulation of atrial Kv1.5 channel during AF. H2S-induced inhibition of atrial Ang II upregulation and ROS production are involved. H2S decreases Kv1.5 by inactivation of Nox4-related P-Smad2/3 and P-ERK 1/2 signaling.