BMP-7 attenuated silica-induced pulmonary fibrosis through modulation of the balance between TGF-β/Smad and BMP-7/Smad signaling pathway
详细信息 查看全文
- 作者：Di Lianga ; b ; Yan Wanga ; b ; Zhonghui Zhua ; b ; Gengxia Yangc ; Guoliang Ana ; b ; Xiaoli Lia ; b ; Piye Niua ; b ; Li Chena ; b ; Lin Tiana ; b ; tian_lin@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Silica ; Fibrosis ; Bone morphogenetic protein-7
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：5 January 2016
- 年：2016
- 卷：243
- 期：Complete
- 页码：72-81
- 全文大小：2350 K
文摘
- •
Silica-induced EMT and fibrosis in RLE-6TN cells in a dose-dependent manner.
- •
Silica-induced fibrosis associated with Smad signaling balance.
- •
BMP-7 had both preventative and therapeutic anti-fibrotic effects.