Upregulation of integrin expression on monocytes in multiple sclerosis patients treated with natalizumab
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- 作者：Simone Dallaria ; Diego Franciottab ; Silvia Carluccioa ; Lucia Signorinia ; Matteo Gastaldib ; Elena Colombob ; Roberto Bergamaschib ; Francesca Eliaa ; Sonia Villania ; Pasquale Ferrantea ; c ; Serena Delbuea ; serena.delbue@unimi.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Multiple sclerosis ; Natalizumab ; Monocytes
- 刊名：Journal of Neuroimmunology
- 出版年：2015
- 出版时间：15 October 2015
- 年：2015
- 卷：287
- 期：Complete
- 页码：76-79
- 全文大小：450 K
文摘
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Eleven natalizumab-treated multiple sclerosis patients were followed for one year.
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Changes in monocytes, their subsets and CD49 and CD18 expression were evaluated.
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Increased expression of CD49d/CD18 on CD14+CD16+ and CD14dimCD16+ cells was found.
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The results suggest a role for monocyte subsets as mediators of natalizumab effects.
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