Transgenic chickens as bioreactors for protein-based drugs

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• 作者：Lillico ; Simon G. ; McGrew ; Michael J. ; Sherman ; Adrian ; Sang ; Helen M.
• 关键词：Drug Discovery ; Pharmaceutical Science ; Biochemistry ; Biotechnology ; Therapeutic protein ; Post-translational modification ; Glycosylation ; Production flock ; Retroviral vector ; Gene transfer
• 刊名：Drug Discovery Today
• 出版年：2005
• 出版时间：February 1, 2005
• 年：2005
• 卷：10
• 期：3
• 页码：191-196
• 全文大小：1.03 M

文摘

The potential of using transgenic animals for the synthesis of therapeutic proteins was suggested over twenty years ago. Considerable progress has been made in developing methods for the production of transgenic animals and specifically in the expression of therapeutic proteins in the mammary glands of cows, sheep and goats. Development of transgenic hens for protein production in eggs has lagged behind these systems. The positive features associated with the use of the chicken in terms of cost, speed of development of a production flock and potentially appropriate glycosylation of target proteins have led to significant advances in transgenic chicken models in the past few years.