RNAi-mediated silencing of HLA A2 suppressed acute rejection against human fibroblast xenografts in the striatum of 6-OHDA lesioned rats
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- 作者：Caixia Liang ; Yunzhi Xu ; Deyu Zheng ; Xiaohong Sun ; Qunyuan Xu ; Deyi Duan
- 关键词：HLA A2 ; RNA interfering ; Xenotransplantation ; Graft rejection ; Parkinson's disease
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：297
- 期：Complete
- 页码：28-37
- 全文大小：2190 K
文摘
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Striatal human fibroblast grafts increase peripheral CD4/CD8 T-cell ratio in the rat.
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Human fibroblast grafts increase the number of CD4 and CD8 T-cells in the rat brain.
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RNAi-silence reduces HLA A2 protein levels in human cells grafted in the rat brain.
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HLA A2 silence reduces No of CD4, CD8 cells in the brain and CD4 cells in the blood.
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HLA A2-silenced TH-grafts alleviate PD rat motor deficits and improve cell survival.