Most VMS deposits in Mexico occur close to terrane boundaries. They occur mostly in the southern half of the Guerrero composite terrane (GCT) and on the eastern part of the Alisitos arc. They occur also on the western part of the continental margin of Oaxaquia and the Parral terrane. These occurred in back-arc settings or within juvenile and slightly evolved arcs. No VMS deposits are known to occur in the northern half of the GCT. Inclusion fluids from the studied VMS deposits span general ranges of salinities between 2.5 and 20 wt.% NaCl equiv. Temperatures of homogenization range between 110° and 420 °C. Such variety reflects the entrainment of both seawater (unmodified and/or deeply circulated) and magmatic fluids. The highest temperature and salinity values occur distinctively in the stockwork of the Tizapa deposit. δ34S values for the studied VMS deposits reflect different sources of sulfur.