Personality modulates proportions of CD4+ regulatory and effector T cells in response to socially induced stress in a rodent of wild origin
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- 作者：Marylin Rangassamya ; 1 ; Sara Khaleghparast Atharib ; c ; 1 ; Raquel Monclú ; sd ; a ; Marie-Christophe Boissierb ; c ; e ; Natacha Bessisb ; c ; natacha.bessis@univ-paris13.fr" class="auth_mail" title="E-mail the corresponding author ; Heiko G. Rö ; dela ; heiko.rodel@leec.univ-paris13.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Corticosteroid metabolites ; Effector T cells ; Immunosuppression ; Individual differences ; Regulatory T cells ; Social stress
- 刊名：Physiology & Behavior
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：167
- 期：Complete
- 页码：255-264
- 全文大小：619 K
文摘
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We studied personality-related responses in cellular immunity to social stress.
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Mice of wild origin were phenotyped as high (HAN) and low (LAN) anxious/neophobic.
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Socially stressed HAN showed stronger increases in corticosteroids than LAN.
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Stressed HAN had a higher % of regulatory T, and less effector T cells than LAN.
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Results suggest that personality alters immunomodulatory effects of social stress.