We identified Perillyl alcohol I as an inhibitor of HIF-1α activation from the lavender, cherries and mint.
Perillyl alcohol inhibits mTOR/4E-BP1 signaling pathways
Perillyl alcohol efficiently scavenges activity of cellular ROS.
Perillyl alcohol could be a valuable candidate for the intervention of HIF-1α-dependent anticancer activity.
POH inhibits growth of HCT116 cells in a xenograft tumor model.