5HT3 receptors: Target for new antidepressant drugs
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- 作者：Deepali Gupta ; deepaligupta2010@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Visakh Prabhakar visakh512@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Mahesh Radhakrishnan rmaheshbits@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Depression ; 5HT3 receptors ; CNS distribution ; Neurotransmitter ; Oxidative stress ; HPA-axis
- 刊名：Neuroscience & Biobehavioral Reviews
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：64
- 期：Complete
- 页码：311-325
- 全文大小：2365 K
文摘
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5HT3 receptors are the only ligand gated Cys-loop ‘cationotropic’ receptors.
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5HT3 receptors are abundantly distributed in discrete brain regions.
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5HT3 receptor antagonists have antidepressant activity.
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5HT3 receptor antagonists can normalize altered neurotransmitter activity, HPA-axis hyperactivity, oxidative stress and neuroplasticity.
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5HT3 receptors may be an alternative target in the management of depression.