Synthesis of chiral fluorine-containing compounds via Pd-catalyzed asymmetrical allylations of dimethyl 2-fluoromalonate using sulfonamide-pyridine ligands
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- 作者：Min Zhang ; Mingzhu Zhao ; Purui Zheng ; Hongbo Zhang ; Xiaoming Zhao ; xmzhao08@mail.tongji.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Fluorine-containing compound ; Dimethyl 2-fluoromalonate ; Allylation ; Sulfonamide-pyridine ligand ; Enantioselectivity
- 刊名：Journal of Fluorine Chemistry
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：189
- 期：Complete
- 页码：13-21
- 全文大小：793 K
文摘
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A set of new chiral sulfonamide-pyridine ligands has been synthesized from a new chiral sulfoxide.
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The Pd/sulfonamide-pyridine ligand catalyst provided the monofluorinated allylic products with high ee.
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The sulfonamide moiety on the ligand has a significant effect on the enantiocontrol.