miR-411-5p inhibits proliferation and metastasis of breast cancer cell via targeting GRB2
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- 作者：Yunda Zhanga ; b ; 1 ; Guoxing Xua ; c ; 1 ; Gang Liua ; 1 ; Yongzhi Yea ; Chuankai Zhanga ; b ; Chuannan Fanb ; Haibin Wanga ; c ; Huali Caia ; c ; Rui Xiaoa ; c ; Zhengjie Huanga ; c ; huangzhengjie@xmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Qi Luoa ; c ; luoqixmzsh@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：miR-411-5p ; GRB2 ; Breast cancer ; Proliferation ; Metastasis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：5 August 2016
- 年：2016
- 卷：476
- 期：4
- 页码：607-613
- 全文大小：2462 K
文摘
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miR-411-5p is downregulated in breast cancer tissues and cell lines.
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miR-411-5p inhibits breast cancer cells growth, migration and invasion in vitro.
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GRB2 is a direct target of miR-411-5p in breast cancer.
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GRB2 is overexpressed in breast cancer and associates with disease outcome.
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miR-411-5p suppresses breast cancer progression though GRB2-SOS-Ras pathway.