The immunomodulatory activities of pullulan and its derivatives in human pDC-like CAL-1 cell line
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- 作者：Fang Wanga ; b ; 1 ; Linan Qiaob ; 1 ; Liwei Chena ; Cong Zhangb ; Yan Wangb ; Yinsong Wangb ; Yuanyuan Liub ; liuyuanyuan01@tmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Ning Zhanga ; b ; zhangning@tmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Pullulan ; Derivative ; Immunomodulatory ; Human pDC-like CAL-1 cell line
- 刊名：International Journal of Biological Macromolecules
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：86
- 期：Complete
- 页码：764-771
- 全文大小：2137 K
文摘
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Acidic and alkaline pullulan derivative, called respectively SUPL and AMPL, were synthesized and characterized.
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Pullulan, SUPL and AMPL activated TLRs-mediated MyD88-dependent type I IFN and NF-κB signal pathways in CAL-1 cells.
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AMPL showed remarkably enhanced immunomodulatory activities compared to pullulan and SUPL.
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AMPL showed great potential to be used as a potent immunomodulatory agent.