Environmental chemicals active as human antiandrogens do not activate a stickleback androgen receptor but enhance a feminising effect of oestrogen in roach
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- 作者：Anke Langea ; A.Lange@exeter.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Marion Sebirea ; b ; Pawel Rostkowskic ; 1 ; Takeshi Mizutanid ; Shinichi Miyagawad ; Taisen Iguchid ; Elizabeth M. Hillc ; Charles R. Tylera ; C.R.Tyler@exeter.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Feminisation ; Antiandrogen ; Oestrogen ; Mixture ; Fish ; Endocrine disruption
- 刊名：Aquatic Toxicology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：168
- 期：Complete
- 页码：48-59
- 全文大小：1602 K
文摘
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Anti-androgenic chemicals (in humans) did not activate stickleback ARs in vitro.
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Anti-androgenic chemicals (in humans) did not activate stickleback ARs in vivo.
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Bioavailable antiandrogens did not feminise the reproductive duct in roach.
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Antiandrogens enhanced a feminising effect of oestrogens in roach.
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Evidence for species differences in responses to antiandrogens.